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// ==========================================================================
// SeqAn - The Library for Sequence Analysis
// ==========================================================================
// Copyright (c) 2006-2018, Knut Reinert, FU Berlin
// All rights reserved.
//
// Redistribution and use in source and binary forms, with or without
// modification, are permitted provided that the following conditions are met:
//
// * Redistributions of source code must retain the above copyright
// notice, this list of conditions and the following disclaimer.
// * Redistributions in binary form must reproduce the above copyright
// notice, this list of conditions and the following disclaimer in the
// documentation and/or other materials provided with the distribution.
// * Neither the name of Knut Reinert or the FU Berlin nor the names of
// its contributors may be used to endorse or promote products derived
// from this software without specific prior written permission.
//
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
// AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
// IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
// ARE DISCLAIMED. IN NO EVENT SHALL KNUT REINERT OR THE FU BERLIN BE LIABLE
// FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
// DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
// SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
// CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT
// LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY
// OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH
// DAMAGE.
//
// ==========================================================================
// Author: Tobias Rausch <rausch@embl.de>
// Author: Anne-Katrin Emde <anne-katrin.emde@fu-berlin.de>
// ==========================================================================
#ifndef SEQAN_INCLUDE_SEQAN_GRAPH_ALIGN_GRAPH_ALGORITHM_REFINE_ALIGNGRAPH_H_
#define SEQAN_INCLUDE_SEQAN_GRAPH_ALIGN_GRAPH_ALGORITHM_REFINE_ALIGNGRAPH_H_
//SEQAN_NO_DDDOC: do not generate documentation for this file
namespace seqan {
///////////////////////////////////////////////////////////////////////////////////////////////////////
//Functios for Align Graphs
//project onto other sequence for Graph<Alignment>
template<typename TAlignment,typename TId1, typename TPos1, typename TId2, typename TPos2, typename TValue,typename TMap>
void
_getOtherSequenceAndProject(Graph<TAlignment> & segment,
TValue seg_num,
TMap &,
TId1 seq_i_id,
TPos1 pos_i,
TId2 & seq_j_id,
TPos2 & pos_j)
{
getProjectedPosition(segment,seg_num,seq_i_id, pos_i,seq_j_id,pos_j);
}
//given seq and segment, get the sequenceId (seq_i) and its begin and end
//if seq = 0 get first sequence (that takes part in the segment match)
//if seq = 1 get second sequence
template<typename TAlign, typename TId, typename TPosition, typename TId2>
void
_getSeqBeginAndEnd(Graph<TAlign> & segment,
std::map<const void * ,int> &,
TId & seq_i_id,
TPosition & begin_i,
TPosition & end_i,
TId2 seq)
{
//walk through edges, take first edge, target, source,
//define: seq == 0 ==> seq_i_id = id of source of first edge
// seq == 1 ==> seq_i_id = id of target of first edge
typedef Graph<TAlign> TGraph;
typedef typename VertexDescriptor<TGraph>::Type TVertexDescriptor;
typedef typename Iterator<TGraph, EdgeIterator>::Type TEdgeIterator;
TEdgeIterator ed_it(segment);
//goBegin(ed_it);
if(seq==0)
{
TVertexDescriptor src = sourceVertex(ed_it);
seq_i_id = sequenceId(segment,src);
}
else
{
TVertexDescriptor trg = targetVertex(ed_it);
seq_i_id = sequenceId(segment,trg);
}
begin_i = getFirstCoveredPosition(segment,seq_i_id);
end_i = getLastCoveredPosition(segment,seq_i_id);
}
//////////////////////////
//for Graph<TAlign>
//vorsichtig! noch nicht richtig, bis jetzt nur ungapped exact matches...
//template<typename TScore,typename TStringSet,typename TAlignment,typename TValue>
//typename Value<TScore>::Type
//_getRefinedMatchScore(TScore & score_type,
// TStringSet & seqs,
// Graph<TAlignment> & segment,
// TValue pos_i,
// TValue pos_j,
// TValue len)
//{
// int pseudo_map = 0;
// TValue pos_j_check,seq_j_id;
// _getOtherSequenceAndProject(segment,pseudo_map,seq_i_id,pos_i,seq_j_id,pos_j_check);
// SEQAN_ASSERT(pos_j_check==pos_j);
// TValue last_pos_i = pos_i + len;
// TValue last_pos_j;
// _getOtherSequenceAndProject(segment,pseudo_map,seq_i_id,last_pos_i,seq_j_id,last_pos_j);
//
//// typename Infix<typename Value<TStringSet>::Type>::Type label0 = infix(getValueById(seqs,seq_i_id),pos_i,last_pos_i);
//// typename Infix<typename Value<TStringSet>::Type>::Type label1 = infix(getValueById(seqs,seq_j_id),pos_j,last_pos_j);
//
// typename Value<TScore>::Type score = 0;
// TValue i = 0;
// while (i < len)
// {
// next_pos_j = getProjectedPosition(segment,seq_i_id,pos_i);
// //gaps
// if(pos_j+1 != next_pos_j)
// {
// if(pos_j == next_pos_j)
// {
// score += scoreGapExtend(score_type);
// ++pos_i;
// ++i;
// continue;
// }
// }
// pos_j = next_pos_j;
// score += score(score_type,getValueById(seqs,seq_i_id)[pos_i],getValueById(seqs,seq_j_id)[pos_j]);
// ++i;
// ++pos_i;
// }
//
//
//
//
//
//
//
//
// typename Infix<typename Value<TStringSet>::Type>::Type label0 = label(segment,stringSet(segment)[0]);
// typename Infix<typename Value<TStringSet>::Type>::Type label1 = label(segment,stringSet(segment)[1]);
//
//
// //typename Infix<typename Value<TStringSet>::Type>::Type label0 = label(segment,0);
// //typename Infix<typename Value<TStringSet>::Type>::Type label1 = label(segment,1);
// int i = 0;
// typename Value<TScore>::Type ret_score = 0;
// while(i < len)
// {
// ret_score += score(score_type,label0[i],label1[i]);
// ++i;
// }
// //ret_score = scoreMatch(score_type);
// //ret_score *= len;
// return ret_score;
//}
//////////////////////////
// get score for part of pairwise alignment graph starting in pos_i in first sequence and in
// pos_j in second sequence, and with length len and len_j respectively
// only for exact refinement
template<typename TScoreValue,typename TScoreSpec,typename TStringSet,typename TAlignment,typename TValue>
TScoreValue
_getRefinedMatchScore(Score<TScoreValue,TScoreSpec> & score_type,
TStringSet & seqs,
Graph<TAlignment> & segment,
TValue pos_i,
TValue pos_j,
TValue len,
TValue len_j)
{
typedef Graph<TAlignment> TGraph;
typedef typename VertexDescriptor<TGraph>::Type TVertexDescriptor;
typedef typename Iterator<TGraph, EdgeIterator>::Type TEdgeIterator;
typedef typename Iterator<TGraph, OutEdgeIterator>::Type TOutEdgeIterator;
typedef typename TGraph::TPosToVertexMap TPosToVertexMap;
typedef typename TPosToVertexMap::const_iterator TVertexMapIter;
TVertexDescriptor nilVertex = getNil<TVertexDescriptor>();
TValue seq_i_id;
TEdgeIterator ed(segment);
//goBegin(ed);
seq_i_id = sequenceId(segment,sourceVertex(ed));
int pseudo_map = 0;
TValue pos_j_check,seq_j_id;
_getOtherSequenceAndProject(segment,pseudo_map,seq_i_id,pos_i,seq_j_id,pos_j_check);
SEQAN_ASSERT(pos_j_check==pos_j);
TValue last_pos_j = pos_j + len_j;
TScoreValue ret_score = 0;
bool last_one_was_aligned = false;
while(len != 0)
{
TValue rest = 0;
TVertexMapIter it = segment.data_pvMap.upper_bound(std::make_pair(seq_i_id, pos_i));
// it->second is nilVertex if pos_i lies within gap
if(it->second == nilVertex)
{
++it;
if(it != segment.data_pvMap.end() && it->first.first == seq_i_id)
{
rest = fragmentBegin(segment,it->second)-pos_i;
last_one_was_aligned = false;
if(rest < len)//add rest many gaps
ret_score += rest * scoreGapExtend(score_type);
else
{//add len many gaps
ret_score += len * scoreGapExtend(score_type);
return ret_score; //and done!
}
}
else
{//add len many gaps
ret_score += len * scoreGapExtend(score_type);
return ret_score; //and done!
}
}
else{
TVertexDescriptor vd = it->second;
rest = fragmentBegin(segment,vd)+fragmentLength(segment,vd)-pos_i;
TOutEdgeIterator ed_it(segment,vd);
if(!atEnd(ed_it)) //aligned stretch
{
if(last_one_was_aligned)
{
TValue next_pos_j,temp;
getProjectedPosition(segment,seq_i_id,pos_i,temp,next_pos_j);
ret_score += (next_pos_j-pos_j) * scoreGapExtend(score_type);
pos_j = next_pos_j;
}
last_one_was_aligned = true;
TValue i = 0;
while(i < rest && i < len)
{
ret_score += score(score_type,getValueById(seqs,seq_i_id)[pos_i++],getValueById(seqs,seq_j_id)[pos_j++]);
++i;
}
if(rest>len) return ret_score; //done (last_pos_i is somewhere inside the current node)
else
{//last_pos_i is the first position of the next node
if(rest == len) //check if there is an unalgined stretch on seq_j_id that needs to be included
{
if(pos_j != last_pos_j)
ret_score += (last_pos_j-pos_j) * scoreGapExtend(score_type);
}
}
}
else //gap
{
last_one_was_aligned = false;
if(rest < len)//add rest many gaps
ret_score += rest * scoreGapExtend(score_type);
else
{//add len many gaps
ret_score += len * scoreGapExtend(score_type);
return ret_score; //and done!
}
}
}
len -= rest;
}
return ret_score;
}
} // namespace seqan
#endif // #ifndef SEQAN_INCLUDE_SEQAN_GRAPH_ALIGN_GRAPH_ALGORITHM_REFINE_ALIGNGRAPH_H_
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