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// ==========================================================================
// SeqAn - The Library for Sequence Analysis
// ==========================================================================
// Copyright (c) 2006-2018, Knut Reinert, FU Berlin
// All rights reserved.
//
// Redistribution and use in source and binary forms, with or without
// modification, are permitted provided that the following conditions are met:
//
// * Redistributions of source code must retain the above copyright
// notice, this list of conditions and the following disclaimer.
// * Redistributions in binary form must reproduce the above copyright
// notice, this list of conditions and the following disclaimer in the
// documentation and/or other materials provided with the distribution.
// * Neither the name of Knut Reinert or the FU Berlin nor the names of
// its contributors may be used to endorse or promote products derived
// from this software without specific prior written permission.
//
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
// AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
// IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
// ARE DISCLAIMED. IN NO EVENT SHALL KNUT REINERT OR THE FU BERLIN BE LIABLE
// FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
// DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
// SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
// CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT
// LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY
// OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH
// DAMAGE.
//
// ==========================================================================
// Author: Tobias Rausch <rausch@embl.de>
// Author: Anne-Katrin Emde <anne-katrin.emde@fu-berlin.de>
// ==========================================================================
#ifndef SEQAN_INCLUDE_SEQAN_GRAPH_ALGORITHM_REFINE_ANNOTATION_H_
#define SEQAN_INCLUDE_SEQAN_GRAPH_ALGORITHM_REFINE_ANNOTATION_H_
//SEQAN_NO_DDDOC: do not generate documentation for this file
namespace seqan {
template<typename TSequence, typename TValue, typename TSpec = Simple>
class Annotation;
template<typename TSequence,typename TValue>
class Annotation<TSequence,TValue,Simple>{
public:
typedef typename Id<TSequence>::Type TId_;
typedef typename Position<TSequence>::Type TPos_;
typedef typename Size<TSequence>::Type TSize_;
TId_ data_seq_id;
TPos_ data_begin;
TSize_ data_length;
//String<char> data_label;
TValue data_label;
Annotation()
{
}
Annotation(TId_ seqId, TPos_ begin, TSize_ len, TValue label) :
data_seq_id(seqId),
data_begin(begin),
data_length(len),
data_label(label)
{
}
~Annotation()
{
}
};
template<typename TSequence,typename TValue,typename TSpec>
typename Id<TSequence>::Type&
sequenceId(Annotation<TSequence,TValue,TSpec> & me)
{
return me.data_seq_id;
}
template<typename TSequence,typename TValue,typename TSpec>
typename Position<TSequence>::Type&
fragmentBegin(Annotation<TSequence,TValue,TSpec> & me)
{
return me.data_begin;
}
template<typename TSequence,typename TValue,typename TSpec>
typename Size<TSequence>::Type&
fragmentLength(Annotation<TSequence,TValue,TSpec> & me)
{
return me.data_length;
}
template<typename TSequence,typename TValue,typename TSpec>
TValue
label(Annotation<TSequence,TValue,TSpec> & me)
{
return me.data_label;
}
template<typename TSequence,typename TValue,typename TSpec>
struct Value<Annotation<TSequence,TValue,TSpec> >
{
typedef TValue Type;
};
// default: no annotation given, do nothing
template<typename TValue, typename TAliString, typename TGraph, typename TPropertyMap, typename TStringSet, typename TMap, typename TTagSpec>
inline void
_addAnnotationCuts(String<std::set<TValue> > &,
TAliString &,
String<TGraph> &,
String<TPropertyMap> &,
TStringSet &,
TMap &,
bool,
TValue,
Tag<TTagSpec>)
{
return;
}
//refine positions where annotation changes (borders of annotated stretches)
template<typename TValue, typename TAliString, typename TGraph, typename TPropertyMap, typename TStringSet, typename TMap, typename TAnnoString, typename TTagSpec>
inline void
_addAnnotationCuts(String<std::set<TValue> > & all_nodes,
TAliString & alis,
String<TGraph> & gs,
String<TPropertyMap> & pms,
TStringSet & seq,
TMap & seq_map,
TAnnoString & annotation,
TValue min_fragment_len,
Tag<TTagSpec> tag)
{
//typedef typename Value<TAnnoString>::Type TAnnotation;
typedef typename Iterator<TAnnoString,Standard>::Type TAnnoIter;
typedef typename std::set<TValue>::iterator TSetIterator;
//call function _refine for each position that annotation is given for (the borders of annotated stretches)
TAnnoIter anno_it = begin(annotation,Standard());
TAnnoIter anno_end = end(annotation,Standard());
//for each annotated stretch
while(anno_it != anno_end)
{
TValue seq_i_id = sequenceId(*anno_it);
TValue begin_i = fragmentBegin(*anno_it);
TValue end_i = begin_i + fragmentLength(*anno_it);
TValue seq_i_pos = idToPosition(seq,seq_i_id);
//refine begin
TSetIterator iter = all_nodes[seq_i_pos].find(begin_i);
if(_cutIsValid(all_nodes,seq_i_pos,begin_i,iter,min_fragment_len,tag))
{
all_nodes[seq_i_pos].insert(begin_i);
_refine(begin_i, seq_i_id, seq, seq_map, alis, gs,pms,all_nodes,min_fragment_len,tag);//TStop());
}
//and end position
iter = all_nodes[seq_i_pos].find(end_i);
if(_cutIsValid(all_nodes,seq_i_pos,end_i,iter,min_fragment_len,tag))
{
all_nodes[seq_i_pos].insert(end_i);
_refine(end_i, seq_i_id, seq, seq_map, alis, gs,pms,all_nodes,min_fragment_len,tag);//TStop());
}
++anno_it;
}
}
// add annotation labels to nodes, as given in annotation, store as node properties in pm
template<typename TPropertyMap, typename TStringSet, typename TMap, typename TAnnoString, typename TAliGraph,typename TTagSpec>
inline void
_addNodeAnnotation(TStringSet &,
TMap &,
TAnnoString & annotation,
TPropertyMap & pm,
TAliGraph & ali_g,
Tag<TTagSpec>)
{
resizeVertexMap(pm, ali_g);
typedef typename Value<TAnnoString>::Type TAnnotation;
typedef typename Id<TAnnotation>::Type TId;
typedef typename Position<TAnnotation>::Type TPos;
typedef typename Value<TAnnotation>::Type TLabel;
typedef typename VertexDescriptor<TAliGraph>::Type TVertexDescriptor;
typedef typename Iterator<TAnnoString,Standard>::Type TAnnoIter;
TAnnoIter anno_it = begin(annotation,Standard());
TAnnoIter anno_end = end(annotation,Standard());
//for each annotated stretch
while(anno_it != anno_end)
{
TLabel label_ = label(*anno_it);
TId seq_id = sequenceId(*anno_it);
TPos act_pos = fragmentBegin(*anno_it);
TPos end_pos = act_pos + fragmentLength(*anno_it);
//for each interval that lies within the current segment/fragement/alignment
while(act_pos < end_pos)
{
//get the node represents the current interval (begin_pos until next_cut_pos or end_pos)
TVertexDescriptor act_knot = findVertex(ali_g,seq_id,act_pos);
String<TLabel> property = getProperty(pm, act_knot);
appendValue(property,label_);
assignProperty(pm, act_knot, property);
SEQAN_ASSERT(fragmentBegin(ali_g,act_knot)==act_pos);
//prepare for next interval
act_pos += fragmentLength(ali_g,act_knot);
}
++anno_it;
}
}
// edgescore = alignmentscore * annoscore
// compute annotation score: 2 if vd1 and vd2 share same annotation
// 1 if they are not the same (--> edgescore = alignmentscore)
template<typename TAliGraph,typename TScore, typename TPropertyMap>
typename Value<TScore>::Type
_getRefinedAnnoScore(TAliGraph &,
TPropertyMap & pm,
typename VertexDescriptor<TAliGraph>::Type vd1,
typename VertexDescriptor<TAliGraph>::Type vd2,
TScore &)
{
typedef typename Value<TPropertyMap>::Type TProperty;
//typedef typename Value<TProperty>::Type TChar;
typedef typename Iterator<TProperty,Standard>::Type TIterator;
TIterator prop1_it = begin(property(pm,vd1),Standard());
TIterator prop1_end = end(property(pm,vd1),Standard());
while(prop1_it != prop1_end)
{
TIterator prop2_it = begin(property(pm,vd2),Standard());
TIterator prop2_end = end(property(pm,vd2),Standard());
while(prop2_it != prop2_end)
{
if(*prop2_it==*prop1_it)
return 2;/*scoreMatch(score_type);*/
++prop2_it;
}
++prop1_it;
}
return 1;
}
// default score 1 --> edgescore = alignmentscore
template<typename TAliGraph,typename TScore>
typename Value<TScore>::Type
_getRefinedAnnoScore(TAliGraph &,
bool,
typename VertexDescriptor<TAliGraph>::Type,
typename VertexDescriptor<TAliGraph>::Type,
TScore &)
{
return (typename Value<TScore>::Type) 1;
}
//annotation given,exact refinement, score type given
template<typename TAlignmentString, typename TScoreValue,typename TScoreSpec,typename TAnnoString,typename TOutGraph, typename TSequence, typename TSetSpec>
void
matchRefinement(TAlignmentString & alis,
TAnnoString & anno,
StringSet<TSequence, TSetSpec> & seq,
Score<TScoreValue,TScoreSpec> & score_type,
TOutGraph & ali_graph)
{
//min_fragment_len = 1 ==> Exact cutting
matchRefinement(alis,seq,score_type,ali_graph,1,anno,ExactRefinement());
}
//annotation given,score type given, min fragment length given, if > 1 ==> inexact refinement
template<typename TAlignmentString, typename TScoreValue,typename TScoreSpec,typename TAnnoString, typename TOutGraph, typename TSequence, typename TSetSpec>
void
matchRefinement(TAlignmentString & alis,
TAnnoString & anno,
StringSet<TSequence, TSetSpec> & seq,
Score<TScoreValue,TScoreSpec> & score_type,
TOutGraph & ali_graph,
unsigned int min_frag_len)
{
if(min_frag_len > 1)
matchRefinement(alis,seq,score_type,ali_graph,min_frag_len,anno,InexactRefinement());
else
matchRefinement(alis,seq,score_type,ali_graph,min_frag_len,anno,ExactRefinement());
}
//annotation given,score type not given, min fragment length given, if > 1 ==> inexact refinement
template<typename TAlignmentString, typename TOutGraph, typename TAnnoString, typename TSequence, typename TSetSpec>
void
matchRefinement(TAlignmentString & alis,
TAnnoString & anno,
StringSet<TSequence, TSetSpec> & seq,
TOutGraph & ali_graph,
unsigned int min_frag_len)
{
// Score<int,FakeScore > fake_score;
typename Cargo<TOutGraph>::Type fake_score = 1;
if(min_frag_len > 1)
matchRefinement(alis,seq,fake_score,ali_graph,min_frag_len,anno,InexactRefinement());
else
matchRefinement(alis,seq,fake_score,ali_graph,min_frag_len,anno,ExactRefinement());
}
//annotation given,exact refinement, score type not given
template<typename TAlignmentString,typename TAnnoString, typename TOutGraph, typename TSequence, typename TSetSpec>
void
matchRefinement(TAlignmentString & alis,
TAnnoString & anno,
StringSet<TSequence, TSetSpec> & seq,
TOutGraph & ali_graph)
{
// Score<int,FakeScore > fake_score;
typename Cargo<TOutGraph>::Type fake_score = 1;
matchRefinement(alis,seq,fake_score,ali_graph,1,anno,ExactRefinement());
}
} // namespace seqan
#endif // #ifndef SEQAN_INCLUDE_SEQAN_GRAPH_ALGORITHM_REFINE_ANNOTATION_H_
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