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/*=========================================================================
Copyright (C) 2009 by Stephan Aiche
This program is free software; you can redistribute it and/or
modify it under the terms of the GNU Lesser General Public
License as published by the Free Software Foundation; either
version 3 of the License, or (at your options) any later version.
This program is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU
Lesser General Public License for more details.
You should have received a copy of the GNU General Public License
along with this program. If not, see <https://www.gnu.org/licenses/>.
==========================================================================
$Id$
==========================================================================*/
#ifndef SEQAN_APPS_RR_UTILS_H
#define SEQAN_APPS_RR_UTILS_H
// includes
#include <cmath>
#include <seqan/sequence.h>
using namespace seqan2;
/*
approximated cumulative normal distribution
https://www.sitmo.com/doc/Calculating_the_Cumulative_Normal_Distribution
Abromowitz and Stegun approximation
*/
double cumulated_normal(const double x)
{
const double b1 = 0.319381530;
const double b2 = -0.356563782;
const double b3 = 1.781477937;
const double b4 = -1.821255978;
const double b5 = 1.330274429;
const double p = 0.2316419;
const double c = 0.39894228;
if(x >= 0.0) {
double t = 1.0 / ( 1.0 + p * x );
return (1.0 - c * exp( -x * x / 2.0 ) * t *
( t *( t * ( t * ( t * b5 + b4 ) + b3 ) + b2 ) + b1 ));
}
else {
double t = 1.0 / ( 1.0 - p * x );
return ( c * exp( -x * x / 2.0 ) * t *
( t *( t * ( t * ( t * b5 + b4 ) + b3 ) + b2 ) + b1 ));
}
}
double cumulated_normal(const double x, const double mu, const double sd){
return cumulated_normal(x/sd - mu/sd);
}
int factorial(const int n)
{
if(n < 2) return 1;
else
{
int f = 2;
for(int s = 3; s <= n;++s) f *= s;
return f;
}
}
double poisson(const int k, const double lambda)
{ return (1.0/static_cast<double>(factorial(k))) * pow(lambda,static_cast<double>(k)) * exp((-1.0) * lambda); }
double p_value(const double x,const double mu, const double sd){
return (1.0 - cumulated_normal(x-1,mu,sd));
}
double p_value(const unsigned n_u, const double lambda)
{
double p=0.0;
for(unsigned i = 0; i < n_u;++i)
{ p += poisson(i,lambda); }
return (1 - p);
}
/////////////////////////////////////////////////////////////////////////////
// some accessor stuff for the common repsep structures
// 1. Triple< TAlphabet, .. gapped sequence char
// TId, .. readId
// TReadPos > .. position of the char in ungapped read (gap is length(read) + 1)
/////////////////////////////////////////////////////////////////////////////
template<typename TAlphabet, typename TId, typename TReadPos>
TAlphabet _sequenceCharacter(Triple<TAlphabet, TId, TReadPos> arc)
{
return arc.i1;
}
template<typename TAlphabet, typename TId, typename TReadPos>
TId _readId(Triple<TAlphabet, TId, TReadPos> arc)
{
//IOREV _notio_
return arc.i2;
}
template<typename TAlphabet, typename TId, typename TReadPos>
TReadPos _positionInRead(Triple<TAlphabet, TId, TReadPos> arc)
{
return arc.i3;
}
///////////////////////////////////
template<typename TAlphabet, typename TId, typename TReadPos>
void _setSequenceCharacter(Triple<TAlphabet, TId, TReadPos> & arc, TAlphabet val)
{
arc.i1 = val;
}
template<typename TAlphabet, typename TId, typename TReadPos>
void _setReadId(Triple<TAlphabet, TId, TReadPos> & arc, TId id)
{
arc.i2 = id;
}
template<typename TAlphabet, typename TId, typename TReadPos>
void _setPositionInRead(Triple<TAlphabet, TId, TReadPos> & arc, TReadPos pos)
{
arc.i3 = pos;
}
/////////////////////////////////////////////////////////////////////////////
// 1. Triple< TAlphabet, .. gapped sequence char
// TReadPos > .. position of the char in ungapped read (gap is length(read) + 1)
/////////////////////////////////////////////////////////////////////////////
template<typename TAlphabet, typename TReadPos>
TAlphabet _sequenceCharacter(Pair<TAlphabet, TReadPos> arc)
{
return arc.i1;
}
template<typename TAlphabet, typename TReadPos>
TReadPos _positionInRead(Pair<TAlphabet, TReadPos> arc)
{
return arc.i2;
}
///////////////////////////////////
template<typename TAlphabet, typename TReadPos>
void _setSequenceCharacter(Pair<TAlphabet, TReadPos> & arc, TAlphabet val)
{
arc.i1 = val;
}
template<typename TAlphabet, typename TReadPos>
void _setPositionInRead(Pair<TAlphabet, TReadPos> & arc, TReadPos pos)
{
arc.i2 = pos;
}
/////////////////////////////////////////////////////////////////////////////
// (currently unused parser)
// TODO: check removal
template<typename TReadId>
Pair<TReadId,TReadId>
_parseIds(String<char> & fastaTag){
//IOREV _delcandidate_ marked for removal in code comment
// format is >257,288[id=1,mateId=431]
Pair<TReadId,TReadId> ret;
typedef typename Iterator< String<char> >::Type TIter;
TIter iter = begin(fastaTag);
// first find start of interesting part [
while(value(iter) != '[') ++iter;
// now step to =
while(value(iter) != '=') ++iter;
++iter;
ret.i1 = value(iter);
++iter;
while(value(iter) != ','){
append(ret.i1,value(iter));
++iter;
}
// now step to =
while(value(iter) != '=') ++iter;
++iter;
ret.i2 = value(iter);
++iter;
while(value(iter) != ','){
append(ret.i2,value(iter));
++iter;
}
// after this there will only be the libraryId and so
return ret;
}
template <typename TString>
int _parseGroupId(TString & tag)
{
//IOREV _notio_
String<char> groupId;
for (unsigned i = 0; i < length(tag); ++i)
{
if(static_cast<char>(value(tag,i)) == '-')
{
++i;
while(i < length(tag))
{
append(groupId, static_cast<char>(value(tag,i)));
++i;
}
}
}
return atoi(toCString(groupId));
}
/////////////////////////////////////////////////////////////////////////////
#endif
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