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// ==========================================================================
// SeqAn - The Library for Sequence Analysis
// ==========================================================================
// Copyright (c) 2006-2026, Knut Reinert, FU Berlin
// All rights reserved.
//
// Redistribution and use in source and binary forms, with or without
// modification, are permitted provided that the following conditions are met:
//
// * Redistributions of source code must retain the above copyright
// notice, this list of conditions and the following disclaimer.
// * Redistributions in binary form must reproduce the above copyright
// notice, this list of conditions and the following disclaimer in the
// documentation and/or other materials provided with the distribution.
// * Neither the name of Knut Reinert or the FU Berlin nor the names of
// its contributors may be used to endorse or promote products derived
// from this software without specific prior written permission.
//
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
// AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
// IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
// ARE DISCLAIMED. IN NO EVENT SHALL KNUT REINERT OR THE FU BERLIN BE LIABLE
// FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
// DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
// SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
// CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT
// LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY
// OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH
// DAMAGE.
//
// ==========================================================================
// Author: David Weese <david.weese@fu-berlin.de>
// ==========================================================================
#ifndef SEQAN_HEADER_REPEAT_BASE_H
#define SEQAN_HEADER_REPEAT_BASE_H
#if SEQAN_ENABLE_PARALLELISM
#include <seqan/parallel.h>
#endif // #if SEQAN_ENABLE_PARALLELISM
namespace seqan2 {
/*!
* @class Repeat
* @headerfile <seqan/index.h>
* @brief Store information about a repeat.
*
* @signature template <typename TPos, typename TPeriod>
* struct Repeat;
*
* @tparam TPeriod Type to use for storing the repeat period. Default: 1
* @tparam TPos Type to use for storing positions.
*
* @see findRepeats
*
* @var TPos Repeat::endPosition;
* @brief The end position of the repeat of type <tt>TPos</tt>.
*
* @var TPos Repeat::beginPosition;
* @brief The begin position of the repeat of type <tt>TPos</tt>.
*
* @var TPeriod Repeat::period;
* @brief The period of the repeat of type <tt>TPeriod</tt>.
*/
template <typename TPos, typename TPeriod>
struct Repeat {
TPos beginPosition;
TPos endPosition;
TPeriod period;
};
template <typename TPos, typename TPeriod>
struct Value< Repeat<TPos, TPeriod> > {
typedef TPos Type;
};
template <typename TPos, typename TPeriod>
struct Size< Repeat<TPos, TPeriod> > {
typedef TPeriod Type;
};
template <typename TSize>
struct RepeatFinderParams {
TSize minRepeatLen;
TSize maxPeriod;
};
// custom TSpec for our customized wotd-Index
struct TRepeatFinder;
template <typename TText>
struct Cargo<Index<TText, IndexWotd<TRepeatFinder> > >
{
typedef Index<TText, IndexWotd<TRepeatFinder> > TIndex;
typedef typename Size<TIndex>::Type TSize;
typedef RepeatFinderParams<TSize> Type;
};
// node predicate
template <typename TText, typename TSpec>
bool nodePredicate(Iter<Index<TText, IndexWotd<TRepeatFinder> >, TSpec> &it)
{
// return countOccurrences(it) * nodeDepth(it) >= cargo(container(it)).minRepeatLen;
return countOccurrences(it) * repLength(it) >= cargo(container(it)).minRepeatLen;
}
// monotonic hull
template <typename TText, typename TSpec>
bool nodeHullPredicate(Iter<Index<TText, IndexWotd<TRepeatFinder> >, TSpec> &it)
{
// return nodeDepth(it) <= cargo(container(it)).maxPeriod;
return repLength(it) <= cargo(container(it)).maxPeriod;
}
template <typename TPos>
struct RepeatLess_ : public std::function<bool(TPos, TPos)>
{
// key less
inline bool operator() (TPos const &a, TPos const &b) const {
return posLess(a, b);
}
};
template <typename TValue>
inline bool _repeatMaskValue(TValue const &)
{
// TODO(holtgrew): Maybe use unknownValue<TValue>() instead of specializing for all alphabets, especially since we have Rna5 now and might want Rna5Q later.
return false;
}
template <>
inline bool _repeatMaskValue(Dna5 const &val)
{
return val == unknownValue<Dna5>(); // 'N'
}
template <>
inline bool _repeatMaskValue(Dna5Q const &val)
{
return val == unknownValue<Dna5Q>(); // 'N'
}
template <>
inline bool _repeatMaskValue(Iupac const &val)
{
return val == unknownValue<Iupac>(); // 'N'
}
/*
template <>
inline bool _repeatMaskValue(AminoAcid val)
{
return val == 'X';
}
*/
/*!
* @fn findRepeats
* @headerfile <seqan/index.h>
* @brief Search for repeats in a text.
*
* @signature void findRepeats(repeatString, text, minRepeatLength[, maxPeriod]);
*
* @param[out] repeatString A @link String @endlink of @link Repeat @endlink objects.
* @param[in] text The text to search repeats in. Types: @link ContainerConcept @endlink
* @param[in] minRepeatLength The minimum length each reported repeat must have.
* @param[in] maxPeriod Optionally, the maximal period that reported repeats can have. Default: 1
*
* Subsequences of undefined values/<tt>N</tt>s will always be reported.
*
* @section Examples
*
* The following demonstrates finding repeats of period 3.
*
* @include demos/dox/index/find_repeats.cpp
*
* @code{.console}
* # of repeats: 15
* i == 0, beginPosition = 3, endPosition = 7, period = 1
* i == 1, beginPosition = 46, endPosition = 53, period = 1
* i == 2, beginPosition = 101, endPosition = 105, period = 1
* i == 3, beginPosition = 105, endPosition = 109, period = 1
* i == 4, beginPosition = 164, endPosition = 169, period = 1
* i == 5, beginPosition = 291, endPosition = 297, period = 1
* i == 6, beginPosition = 319, endPosition = 327, period = 1
* i == 7, beginPosition = 400, endPosition = 404, period = 1
* i == 8, beginPosition = 442, endPosition = 446, period = 1
* i == 9, beginPosition = 468, endPosition = 473, period = 1
* i == 10, beginPosition = 476, endPosition = 480, period = 1
* i == 11, beginPosition = 507, endPosition = 513, period = 1
* i == 12, beginPosition = 561, endPosition = 566, period = 1
* i == 13, beginPosition = 623, endPosition = 627, period = 1
* i == 14, beginPosition = 655, endPosition = 659, period = 1
* @endcode
*
* @see AlphabetWithUnknownValueConcept#unknownValue
* @see Repeat
*/
// TODO(holtgrew): minRepeatLength is 1-off.
// period-1 optimization
template <typename TRepeatStore, typename TString, typename TRepeatSize>
inline void findRepeats(TRepeatStore &repString, TString const &text, TRepeatSize minRepeatLen)
{
typedef typename Value<TRepeatStore>::Type TRepeat;
typedef typename Iterator<TString const>::Type TIterator;
typedef typename Size<TString>::Type TSize;
#if SEQAN_ENABLE_PARALLELISM
typedef typename Value<TString>::Type TValue;
if (length(text) > (TSize)(omp_get_max_threads() * 2 * minRepeatLen)) {
// std::cerr << ">>> PARALLEL WABOOGIE!" << std::endl;
// std::cerr << "omp_get_max_threads() == " << omp_get_max_threads() << std::endl;
// Parallel case.
// NOTE(holtgrew): The minimum text length check above makes it impossible that more than two chunks are
// required to form an otherwise too short repeat.
// TODO(holtgrew): Load balancing? Probably not worth it.
String<TSize> splitters;
String<TRepeatStore> threadLocalStores;
// Each threads finds repeats on its chunk in parallel.
#pragma omp parallel
{
// We have to determine the number of available threads at this point. We will use the number of thread
// local stores to determin the number of available threads later on.
#if _OPENMP >= 202011
#pragma omp masked
#else
#pragma omp master
#endif
{
// std::cerr << "omp_get_num_threads() == " << omp_get_num_threads() << std::endl;
computeSplitters(splitters, length(text), omp_get_num_threads());
resize(threadLocalStores, omp_get_num_threads());
} // end of #pragma omp masked
#pragma omp barrier
int const t = omp_get_thread_num();
TRepeatStore & store = threadLocalStores[t];
TRepeat rep;
rep.beginPosition = 0;
rep.endPosition = 0;
rep.period = 1;
// Flags used for force-adding repeats for the chunks that have a left/right neighbour.
bool forceFirst = t > 0;
bool forceLast = (t + 1) < omp_get_num_threads();
// #pragma omp critical
// std::cerr << "omp_get_num_threads() == " << omp_get_num_threads() << std::endl;
TIterator it = iter(text, splitters[t], Standard());
TIterator itEnd = iter(text, splitters[t + 1], Standard());
if (it != itEnd)
{
TValue last = *it;
TSize repLeft = 0;
TSize repRight = 1;
for (++it; it != itEnd; ++it, ++repRight)
{
if (*it != last)
{
// #pragma omp critical
// std::cerr << "t == " << t << ", last == " << last << ", repRight = " << repRight << ", repLeft == " << repLeft << ", minRepeatLen = " << minRepeatLen << ", forceFirst = " << forceFirst << std::endl;
if (_repeatMaskValue(last) || (TRepeatSize)(repRight - repLeft) > minRepeatLen || forceFirst)
{
forceFirst = false;
// insert repeat
rep.beginPosition = splitters[t] + repLeft;
rep.endPosition = splitters[t] + repRight;
// #pragma omp critical
// std::cerr << " t == " << t << ", append" << std::endl;
appendValue(store, rep);
}
repLeft = repRight;
last = *it;
}
}
// #pragma omp critical
// std::cerr << "t == " << t << ", last == " << last << ", repRight = " << repRight << ", repLeft == " << repLeft << ", minRepeatLen = " << minRepeatLen << ", forceLast = " << forceLast << std::endl;
if (_repeatMaskValue(last) || (TRepeatSize)(repRight - repLeft) > minRepeatLen || forceLast)
{
// Insert repeat but only if it is not already in there.
if (empty(store) || (back(store).beginPosition != repLeft && back(store).endPosition != repRight))
{
rep.beginPosition = splitters[t] + repLeft;
rep.endPosition = splitters[t] + repRight;
// #pragma omp critical
// std::cerr << " t == " << t << ", append" << std::endl;
appendValue(store, rep);
}
}
}
} // end of #pragma omp parallel
// std::cerr << ",-- REPEATS BEFORE MENDING\n";
// for (unsigned i = 0; i < length(threadLocalStores); ++i)
// {
// std::cerr << "| i = " << i << std::endl;
// for (unsigned j = 0; j < length(threadLocalStores[i]); ++j)
// std::cerr << "| threadLocalStores[" << i << "][" << j << "] == {" << threadLocalStores[i][j].beginPosition << ", " << threadLocalStores[i][j].endPosition << "}" << std::endl;
// }
// std::cerr << "`--" << std::endl;
// Mend the splice points.
//
// We will copy out infixes described by fromPositions.
String<Pair<TSize> > fromPositions;
resize(fromPositions, length(threadLocalStores));
for (unsigned i = 0; i < length(fromPositions); ++i)
{
fromPositions[i].i1 = 0;
fromPositions[i].i2 = length(threadLocalStores[i]);
}
// First, merge repeats spanning blocks. Do this iteratively until all has been merged.
bool anyChange;
do
{
anyChange = false;
int lastNonEmpty = -1;
for (unsigned i = 0; i < length(threadLocalStores); ++i)
{
if (fromPositions[i].i1 == fromPositions[i].i2)
continue; // Skip empty buckets.
if (lastNonEmpty != -1)
{
bool const adjacent = back(threadLocalStores[lastNonEmpty]).endPosition == front(threadLocalStores[i]).beginPosition;
bool const charsEqual = text[back(threadLocalStores[lastNonEmpty]).beginPosition] == text[front(threadLocalStores[i]).beginPosition];
if (adjacent && charsEqual)
{
anyChange = true;
back(threadLocalStores[lastNonEmpty]).endPosition = front(threadLocalStores[i]).endPosition;
fromPositions[i].i1 += 1;
}
}
if (fromPositions[i].i1 != fromPositions[i].i2)
lastNonEmpty = i;
}
}
while (anyChange);
// Then, remove any repeats in the beginning and end of blocks that are too short.
for (unsigned i = 0; i < length(threadLocalStores); ++i)
{
if (fromPositions[i].i1 == fromPositions[i].i2)
continue;
unsigned j = fromPositions[i].i1;
TRepeatSize len = threadLocalStores[i][j].endPosition - threadLocalStores[i][j].beginPosition;
if (!_repeatMaskValue(text[threadLocalStores[i][j].beginPosition]) && // Never remove mask value.
len <= minRepeatLen)
fromPositions[i].i1 += 1;
if (fromPositions[i].i1 == fromPositions[i].i2)
continue;
j = fromPositions[i].i2 - 1;
len = threadLocalStores[i][j].endPosition - threadLocalStores[i][j].beginPosition;
if (!_repeatMaskValue(text[threadLocalStores[i][j].beginPosition]) && // Never remove mask value.
len <= minRepeatLen)
fromPositions[i].i2 -= 1;
}
// Last, build splitters for output in parallel.
String<unsigned> outSplitters;
appendValue(outSplitters, 0);
for (unsigned i = 0; i < length(threadLocalStores); ++i)
appendValue(outSplitters, back(outSplitters) + fromPositions[i].i2 - fromPositions[i].i1);
// std::cerr << ",-- REPEATS AFTER MENDING\n";
// for (unsigned i = 0; i < length(threadLocalStores); ++i)
// {
// std::cerr << "| i = " << i << std::endl;
// std::cerr << "`--, fromPositions[" << i << "] = (" << fromPositions[i].i1 << ", " << fromPositions[i].i2 << std::endl;
// for (unsigned j = 0; j < length(threadLocalStores[i]); ++j)
// std::cerr << " | threadLocalStores[" << i << "][" << j << "] == {" << threadLocalStores[i][j].beginPosition << ", " << threadLocalStores[i][j].endPosition << "}" << std::endl;
// }
// std::cerr << " `--" << std::endl;
// Allocate memory.
clear(repString);
resize(repString, back(outSplitters));
// Copy back the repeats in parallel.
unsigned nt = length(threadLocalStores);
(void) nt; // Otherwise, GCC 4.6 warns, does not see it used in pragma clause below.
#pragma omp parallel num_threads(nt)
{
int const t = omp_get_thread_num();
arrayCopy(iter(threadLocalStores[t], fromPositions[t].i1, Standard()),
iter(threadLocalStores[t], fromPositions[t].i2, Standard()),
iter(repString, outSplitters[t], Standard()));
} // end of #pragma omp parallel
} else {
#endif // #if SEQAN_ENABLE_PARALLELISM
// Sequential case.
TRepeat rep;
rep.period = 1;
clear(repString);
TIterator it = begin(text, Standard());
TIterator itEnd = end(text, Standard());
if (it == itEnd) return;
TSize repLen = 1;
for (++it; it != itEnd; ++it)
{
if (*it != *(it-1))
{
if (_repeatMaskValue(*(it-1)) || repLen > (TSize)minRepeatLen)
{
// insert repeat
rep.endPosition = it - begin(text, Standard());
rep.beginPosition = rep.endPosition - repLen;
// std::cerr<<"left:"<<rep.beginPosition<<" right:"<<rep.endPosition<<" length:"<<posSub(rep.endPosition,rep.beginPosition)<<" period:"<<rep.period<<std::endl;
appendValue(repString, rep);
}
repLen = 1;
} else
++repLen;
}
if (_repeatMaskValue(*(it-1)) || repLen > (TSize)minRepeatLen)
{
// insert repeat
rep.endPosition = length(text);
rep.beginPosition = rep.endPosition - repLen;
// std::cerr<<"left:"<<rep.beginPosition<<" right:"<<rep.endPosition<<" length:"<<posSub(rep.endPosition,rep.beginPosition)<<" period:"<<rep.period<<std::endl;
appendValue(repString, rep);
}
#if SEQAN_ENABLE_PARALLELISM
}
#endif // #if SEQAN_ENABLE_PARALLELISM
// #pragma omp critical
// {
// std::cerr << "thread #" << omp_get_thread_num() << " REPEATS:";
// for (unsigned i = 0; i < length(repString); ++i) {
// std::cerr << " (" << repString[i].beginPosition << ", " << repString[i].endPosition << ", " << repString[i].period << ")";
// }
// std::cerr << std::endl;
// }
}
// TODO(holtgrew): Why for TString const and StringSet<> const?
template <typename TRepeatStore, typename TString, typename TSpec, typename TRepeatSize>
inline void findRepeats(TRepeatStore &repString, StringSet<TString, TSpec> const &text, TRepeatSize minRepeatLen)
{
typedef typename Value<TRepeatStore>::Type TRepeat;
typedef typename Iterator<TString>::Type TIterator;
typedef typename Value<TString>::Type TValue;
typedef typename Size<TString>::Type TSize;
TRepeat rep;
rep.period = 1;
clear(repString);
for (unsigned i = 0; i < length(text); ++i)
{
TIterator it = begin(text[i], Standard());
TIterator itEnd = end(text[i], Standard());
if (it == itEnd) continue;
TValue last = *it;
TSize repLeft = 0;
TSize repRight = 1;
rep.beginPosition.i1 = i;
rep.endPosition.i1 = i;
for (++it; it != itEnd; ++it, ++repRight)
{
if (last != *it)
{
if (_repeatMaskValue(last) || (TRepeatSize)(repRight - repLeft) > minRepeatLen)
{
// insert repeat
rep.beginPosition.i2 = repLeft;
rep.endPosition.i2 = repRight;
// std::cerr<<"left:"<<rep.beginPosition<<" right:"<<rep.endPosition<<" length:"<<posSub(rep.endPosition,rep.beginPosition)<<" period:"<<rep.period<<std::endl;
appendValue(repString, rep);
}
repLeft = repRight;
last = *it;
}
}
if (_repeatMaskValue(last) || (TRepeatSize)(repRight - repLeft) > minRepeatLen)
{
// insert repeat
rep.beginPosition.i2 = repLeft;
rep.endPosition.i2 = repRight;
// std::cerr<<"left:"<<rep.beginPosition<<" right:"<<rep.endPosition<<" length:"<<posSub(rep.endPosition,rep.beginPosition)<<" period:"<<rep.period<<std::endl;
appendValue(repString, rep);
}
}
}
// main function
template <typename TRepeatStore, typename TText, typename TRepeatSize, typename TPeriodSize>
void findRepeats(TRepeatStore &repString, TText const &text, TRepeatSize minRepeatLen, TPeriodSize maxPeriod)
{
typedef Index<TText, IndexWotd<TRepeatFinder> > TIndex;
typedef typename Size<TIndex>::Type TSize;
typedef typename Iterator<TIndex, TopDown<ParentLinks<> > >::Type TNodeIterator;
typedef typename Fibre<TIndex, FibreSA>::Type const TSA;
typedef typename Infix<TSA>::Type TOccString;
typedef typename Iterator<TOccString>::Type TOccIterator;
typedef typename Value<TRepeatStore>::Type TRepeat;
typedef typename Value<TOccString>::Type TOcc;
typedef std::map<TOcc,TRepeat,RepeatLess_<TOcc> > TRepeatList;
if (maxPeriod < 1) return;
if (maxPeriod == 1)
{
findRepeats(repString, text, minRepeatLen);
return;
}
TIndex index(text);
TRepeatList list;
// set repeat finder parameters
cargo(index).minRepeatLen = minRepeatLen;
cargo(index).maxPeriod = maxPeriod;
TNodeIterator nodeIt(index);
TOccIterator itA, itB, itRepBegin, itEnd;
TRepeat rep;
for (; !atEnd(nodeIt); goNext(nodeIt))
{
if (isRoot(nodeIt)) continue;
// get occurrences
TOccString occ = getOccurrences(nodeIt);
itA = begin(occ, Standard());
itEnd = end(occ, Standard());
itRepBegin = itB = itA;
TSize repLen = repLength(nodeIt); // representative length
if ((TSize)minRepeatLen <= repLen) continue;
TSize diff, period = 0; // period of current repeat
TSize repeatLen = 0; // overall length of current repeat
TSize minLen = minRepeatLen - repLen; // minimum repeat length minus length of representative
for (++itB; itB != itEnd; ++itB)
{
diff = posSub(*itB, *itA);
if (diff != period || getSeqNo(*itA) != getSeqNo(*itB))
{
// is the repeat long enough?
if (repeatLen >= minLen)
// is the repeat self overlapping or connected?
if (parentRepLength(nodeIt) < period && period <= repLen)
{
// insert repeat
rep.beginPosition = *itRepBegin;
rep.endPosition = posAdd(*itA, period);
rep.period = period;
// std::cerr<<"left:"<<rep.beginPosition<<" right:"<<rep.endPosition<<" length:"<<posSub(rep.endPosition,rep.beginPosition)<<" period:"<<rep.period<<std::endl;
list.insert(std::pair<TOcc,TRepeat>(rep.beginPosition, rep));
}
itRepBegin = itA;
period = diff;
repeatLen = 0;
}
repeatLen += period;
itA = itB;
}
// is the last repeat long enough?
if (repeatLen >= minLen)
// is the repeat self overlapping or connected?
if (parentRepLength(nodeIt) < period && period <= repLen)
{
// insert repeat
rep.beginPosition = *itRepBegin;
rep.endPosition = posAdd(*itA, period);
rep.period = period;
// std::cerr<<"left:"<<rep.beginPosition<<" right:"<<rep.endPosition<<" length:"<<posSub(rep.endPosition,rep.beginPosition)<<" period:"<<rep.period<<std::endl;
list.insert(std::pair<TOcc,TRepeat>(rep.beginPosition, rep));
}
}
// copy low-complex regions to result string
clear(repString);
reserve(repString, list.size(), Exact());
typename TRepeatList::const_iterator lit = list.begin();
typename TRepeatList::const_iterator litEnd = list.end();
for (; lit != litEnd; ++lit)
appendValue(repString, (*lit).second);
}
} // namespace seqan2
#endif
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