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// SPDX-FileCopyrightText: 2006-2025 Knut Reinert & Freie Universität Berlin
// SPDX-FileCopyrightText: 2016-2025 Knut Reinert & MPI für molekulare Genetik
// SPDX-License-Identifier: CC0-1.0
//! [include]
#include <seqan3/alignment/configuration/all.hpp>
//! [include]
//! [include_scoring_scheme]
#include <seqan3/alignment/scoring/aminoacid_scoring_scheme.hpp>
#include <seqan3/alignment/scoring/hamming_scoring_scheme.hpp>
#include <seqan3/alignment/scoring/nucleotide_scoring_scheme.hpp>
//! [include_scoring_scheme]
//! [include_gap_cost_affine]
#include <seqan3/alignment/configuration/align_config_gap_cost_affine.hpp>
//! [include_gap_cost_affine]
//! [include_method]
#include <seqan3/alignment/configuration/align_config_method.hpp>
//! [include_method]
//! [include_output]
#include <seqan3/alignment/configuration/align_config_output.hpp>
//! [include_output]
//! [include_band]
#include <seqan3/alignment/configuration/align_config_band.hpp>
//! [include_band]
//! [include_edit]
#include <seqan3/alignment/configuration/align_config_edit.hpp>
//! [include_edit]
#include <seqan3/alphabet/aminoacid/all.hpp>
#include <seqan3/alphabet/nucleotide/all.hpp>
int main()
{
{
//! [method_global_free_end_gaps]
// Example of a semi-global alignment where leading and trailing gaps in the
// second sequence are not penalised:
auto config = seqan3::align_cfg::method_global{seqan3::align_cfg::free_end_gaps_sequence1_leading{false},
seqan3::align_cfg::free_end_gaps_sequence2_leading{true},
seqan3::align_cfg::free_end_gaps_sequence1_trailing{false},
seqan3::align_cfg::free_end_gaps_sequence2_trailing{true}};
//! [method_global_free_end_gaps]
}
{
//! [scoring_scheme]
using namespace seqan3::literals;
// Define a simple scoring scheme with match and mismatch cost and get the score.
seqan3::nucleotide_scoring_scheme nc_scheme{seqan3::match_score{4}, seqan3::mismatch_score{-5}};
auto sc_nc = nc_scheme.score('A'_dna4, 'C'_dna4); // sc_nc == -5.
// Define a amino acid similarity matrix and get the score.
seqan3::aminoacid_scoring_scheme aa_scheme{};
aa_scheme.set_similarity_matrix(seqan3::aminoacid_similarity_matrix::blosum30);
auto sc_aa = aa_scheme.score('M'_aa27, 'K'_aa27); // sc_aa == 2.
//! [scoring_scheme]
}
{
//! [gap_cost_affine]
// Define a gap scheme with custom gap scores.
seqan3::align_cfg::gap_cost_affine affine_scheme{seqan3::align_cfg::open_score{-10},
seqan3::align_cfg::extension_score{-1}};
int open_score = affine_scheme.open_score; // == -10
int extension_score = affine_scheme.extension_score; // == -1
//! [gap_cost_affine]
}
{
//! [output]
// Configure the alignment to only compute the score.
auto cfg = seqan3::align_cfg::output_score{};
//! [output]
}
{
//! [band]
// Configure a banded alignment.
auto cfg = seqan3::align_cfg::band_fixed_size{seqan3::align_cfg::lower_diagonal{-4},
seqan3::align_cfg::upper_diagonal{4}};
//! [band]
}
{
//! [edit]
// Configure an edit distance alignment.
auto cfg = seqan3::align_cfg::method_global{} | seqan3::align_cfg::edit_scheme;
//! [edit]
}
}
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