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/************************************************************************
*
* Copyright (C) 2017-2025 IRCAD France
* Copyright (C) 2017-2020 IHU Strasbourg
*
* This file is part of Sight.
*
* Sight is free software: you can redistribute it and/or modify it under
* the terms of the GNU Lesser General Public License as published by
* the Free Software Foundation, either version 3 of the License, or
* (at your option) any later version.
*
* Sight is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
* GNU Lesser General Public License for more details.
*
* You should have received a copy of the GNU Lesser General Public
* License along with Sight. If not, see <https://www.gnu.org/licenses/>.
*
***********************************************************************/
#ifdef WIN32
#pragma warning(disable:4701)
#endif
#include "automatic_registration.hpp"
#include "filter/image/detail/itk_image_caster.hpp"
#include <io/itk/helper/transform.hpp>
#include <io/itk/itk.hpp>
#include <itkCommand.h>
#include <itkCorrelationImageToImageMetricv4.h>
#include <itkEuler3DTransform.h>
#include <itkImage.h>
#include <itkImageMomentsCalculator.h>
#include <itkImageRegistrationMethodv4.h>
#include <itkImageToImageMetricv4.h>
#include <itkIntTypes.h>
#include <itkLinearInterpolateImageFunction.h>
#include <itkMattesMutualInformationImageToImageMetricv4.h>
#include <itkMeanSquaresImageToImageMetricv4.h>
#include <itkNearestNeighborInterpolateImageFunction.h>
#include <itkRegularStepGradientDescentOptimizerv4.h>
#include <algorithm>
#include <numeric>
namespace sight::filter::image
{
using registered_image_t = itk::Image<float, 3>;
/// Numeric type used for internal computations.
using real_t = double;
using optimizer_t = itk::RegularStepGradientDescentOptimizerv4<real_t>;
/// Shrink factors per level and smoothing sigmas per level
using multi_resolution_parameters_t = std::vector<std::pair<itk::SizeValueType, real_t> >;
using transform_t = itk::Euler3DTransform<real_t>;
using registration_method_t = itk::ImageRegistrationMethodv4<registered_image_t, registered_image_t, transform_t>;
//------------------------------------------------------------------------------
static inline double compute_volume(const data::image& _img)
{
const auto& spacing = _img.spacing();
const auto& size = _img.size();
SIGHT_ASSERT(
"Degenerated image. Spacing and size should be of the same dimension.",
spacing.size() == size.size()
);
const double voxel_volume = std::accumulate(spacing.begin(), spacing.end(), 1., std::multiplies<>());
const std::size_t nb_voxels = std::accumulate(
size.begin(),
size.end(),
std::size_t(1),
std::multiplies<>()
);
return voxel_volume * static_cast<double>(nb_voxels);
}
//------------------------------------------------------------------------------
class registration_observer : public itk::Command
{
public:
using self_t = registration_observer;
using superclass = itk::Command;
using Pointer = itk::SmartPointer<self_t>;
itkNewMacro(self_t)
/// Command to be executed. Updates the progress bar.
void Execute(itk::Object* _caller, const itk::EventObject& _event) override
{
const itk::Object* const_caller = _caller;
Execute(const_caller, _event);
}
/// Const overload of the above method.
void Execute(const itk::Object* /*caller*/, const itk::EventObject& _event) override
{
{
if(itk::IterationEvent().CheckEvent(&_event))
{
m_iteration_callback();
}
}
}
//------------------------------------------------------------------------------
void set_callback(std::function<void()> _callback)
{
m_iteration_callback = _callback;
}
private:
/// Constructor, initializes progress dialog and sets the user cancel callback.
registration_observer() = default;
std::function<void()> m_iteration_callback;
};
/**
* @brief Static class for automatic image registration. Uses the newer ITKv4 registration framework.
*/
class automatic_registration
{
public:
using iteration_callback_t = std::function<void ()>;
automatic_registration() noexcept = default;
virtual ~automatic_registration() noexcept = default;
/**
* @brief find a rigid transform matching the reference image with the target image.
* @param[in] _target target, i.e. the static image.
* @param[in] _reference reference, i.e. the image that will be transformed into the target.
* @param[out] _trf the resulting rigid transform.
* @param[in] _metric the metric to be used for registration.
* @param[in] _multi_resolution_parameters Shrink factors per level and smoothing sigmas per level
* @param[in] _sampling_percentage the percentage of sample to use for registration
* @param[in] _min_step minimum step for used by optimizer for each iteration.
* @param[in] _max_iterations the maximum number of iterations
*/
void register_image(
const data::image& _target,
const data::image& _reference,
data::matrix4& _trf,
metric_t _metric,
const multi_resolution_parameters_t& _multi_resolution_parameters,
real_t _sampling_percentage = 1.0,
double _min_step = 0.0001,
std::uint64_t _max_iterations = 200,
iteration_callback_t _callback = nullptr
);
void stop_registration() const;
/// Current metric evaluated by the optimizer.
[[nodiscard]] real_t get_current_metric_value() const;
/// Current set of parameters used to evaluate the metric in the optimizer.
[[nodiscard]] const optimizer_t::ParametersType& get_current_parameters() const;
/// Gradient descent relaxation factor.
[[nodiscard]] real_t get_relaxation_factor() const;
/// Gradient descent learning rate.
[[nodiscard]] real_t get_learning_rate() const;
/// Gradient magnitude tolerance.
[[nodiscard]] real_t get_gradient_magnitude_tolerance() const;
/// Current optimizer iteration.
[[nodiscard]] itk::SizeValueType get_current_iteration() const;
/// Current multi-resolution level.
[[nodiscard]] itk::SizeValueType get_current_level() const;
/// Current registration result.
void get_current_matrix(data::matrix4& _trf) const;
void convert_from_eigen_matrix(const transform_t* _itk_mat, data::matrix4& _f4s_mat) const;
optimizer_t::Pointer m_optimizer {nullptr};
registration_method_t::Pointer m_registrator {nullptr};
bool m_invert {false};
};
//------------------------------------------------------------------------------
void automatic_registration::register_image(
const data::image& _target,
const data::image& _reference,
data::matrix4& _trf,
metric_t _metric,
const multi_resolution_parameters_t& _multi_resolution_parameters,
real_t _sampling_percentage,
double _min_step,
std::uint64_t _max_iterations,
iteration_callback_t _callback
)
{
typename itk::ImageToImageMetricv4<registered_image_t, registered_image_t, registered_image_t,
real_t>::Pointer metric;
m_invert = compute_volume(_target) < compute_volume(_reference);
std::reference_wrapper<const data::image> ref = _reference;
std::reference_wrapper<const data::image> tgt = _target;
// Always register images with the largest one being fixed.
// Otherwise, our metric may not find any matching points between them.
if(m_invert)
{
std::swap(ref, tgt);
}
// Convert input images to float. Integer images aren't supported yet.
registered_image_t::Pointer target = sight::filter::image::detail::cast_to<float>(tgt);
registered_image_t::Pointer reference = sight::filter::image::detail::cast_to<float>(ref);
// Choose a metric.
switch(_metric)
{
case mean_squares:
metric =
itk::MeanSquaresImageToImageMetricv4<registered_image_t, registered_image_t, registered_image_t,
real_t>::New();
break;
case normalized_correlation:
metric =
itk::CorrelationImageToImageMetricv4<registered_image_t, registered_image_t, registered_image_t,
real_t>::New();
break;
case mutual_information:
{
auto mut_info_metric =
itk::MattesMutualInformationImageToImageMetricv4<registered_image_t, registered_image_t,
registered_image_t,
real_t>::New();
// TODO: find a strategy to compute the appropriate number of bins or let the user set it.
// More bins means better precision but longer evaluation.
mut_info_metric->SetNumberOfHistogramBins(20);
metric = mut_info_metric;
break;
}
default:
SIGHT_FATAL("Unknown metric");
}
transform_t::Pointer itk_transform = transform_t::New();
itk::Matrix<real_t, 3, 3> m;
itk::Vector<real_t, 3> t;
for(std::uint8_t i = 0 ; i < 3 ; ++i)
{
t[i] = _trf(i, 3);
for(std::uint8_t j = 0 ; j < 3 ; ++j)
{
m(i, j) = _trf(i, j);
}
}
if(m_invert)
{
// Our algorithm assumes m to be orthogonal. If it isn't, an exception will be thrown later on.
m = itk::Matrix<real_t, 3, 3>(m.GetTranspose());
t = -(m * t);
}
// Initialize the transform.
itk::ImageMomentsCalculator<registered_image_t>::Pointer moments_calculator =
itk::ImageMomentsCalculator<registered_image_t>::New();
moments_calculator->SetImage(target);
moments_calculator->Compute();
// Set the rigid transform center to the center of mass of the target image.
// This truly helps the registration algorithm.
itk_transform->SetCenter(moments_calculator->GetCenterOfGravity());
// Setting the offset also recomputes the translation using the offset, rotation and center
// so the matrix needs to be set first.
itk_transform->SetMatrix(m);
itk_transform->SetOffset(t);
// Registration.
m_registrator = registration_method_t::New();
m_optimizer = optimizer_t::New();
m_registrator->SetMetric(metric);
m_registrator->SetOptimizer(m_optimizer);
optimizer_t::ScalesType optimizer_scales(static_cast<unsigned int>(itk_transform->GetNumberOfParameters()));
const double translation_scale = 1.0 / 1000.0;
optimizer_scales[0] = 1.0;
optimizer_scales[1] = 1.0;
optimizer_scales[2] = 1.0;
optimizer_scales[3] = translation_scale;
optimizer_scales[4] = translation_scale;
optimizer_scales[5] = translation_scale;
m_optimizer->SetScales(optimizer_scales);
m_optimizer->SetDoEstimateLearningRateAtEachIteration(true);
m_optimizer->SetMinimumStepLength(_min_step);
// The solution is the transform returned when optimization ends.
m_optimizer->SetReturnBestParametersAndValue(false);
m_optimizer->SetNumberOfIterations(_max_iterations);
// The fixed image isn't transformed, nearest neighbor interpolation is enough.
auto fixed_interpolator = itk::NearestNeighborInterpolateImageFunction<registered_image_t, real_t>::New();
auto moving_interpolator = itk::LinearInterpolateImageFunction<registered_image_t, real_t>::New();
metric->SetFixedInterpolator(fixed_interpolator.GetPointer());
metric->SetMovingInterpolator(moving_interpolator.GetPointer());
// Number of registration stages
SIGHT_ASSERT("255 is the maximum number of steps.", _multi_resolution_parameters.size() < 256);
const auto number_of_levels = std::uint8_t(_multi_resolution_parameters.size());
registration_method_t::ShrinkFactorsArrayType shrink_factors_per_level;
shrink_factors_per_level.SetSize(number_of_levels);
registration_method_t::SmoothingSigmasArrayType smoothing_sigmas_per_level;
smoothing_sigmas_per_level.SetSize(number_of_levels);
// We set the shrink factor and smoothing Sigma for each stage.
for(std::uint8_t i = 0 ; i < number_of_levels ; ++i)
{
const auto& stage_parameters = _multi_resolution_parameters[i];
shrink_factors_per_level[i] = stage_parameters.first;
smoothing_sigmas_per_level[i] = stage_parameters.second;
}
m_registrator->SetInitialTransform(itk_transform);
m_registrator->SetFixedImage(target);
m_registrator->SetMovingImage(reference);
m_registrator->SetMetricSamplingPercentage(_sampling_percentage);
const auto sampling_strategy = _sampling_percentage < 1.0
? registration_method_t::REGULAR : registration_method_t::NONE;
m_registrator->SetMetricSamplingStrategy(sampling_strategy);
m_registrator->SetNumberOfLevels(itk::SizeValueType(number_of_levels));
m_registrator->SetSmoothingSigmasPerLevel(smoothing_sigmas_per_level);
m_registrator->SetShrinkFactorsPerLevel(shrink_factors_per_level);
m_registrator->SetSmoothingSigmasAreSpecifiedInPhysicalUnits(true);
auto observer = registration_observer::New();
if(_callback)
{
observer->set_callback(_callback);
m_optimizer->AddObserver(itk::IterationEvent(), observer);
}
try
{
// Time for lift-off.
m_registrator->Update();
this->get_current_matrix(_trf);
}
catch(itk::ExceptionObject& err)
{
SIGHT_ERROR("Error while registering : " << err);
}
}
//------------------------------------------------------------------------------
void automatic_registration::stop_registration() const
{
if((m_optimizer != nullptr) && (m_registrator != nullptr))
{
// Stop registration by removing all levels.
m_registrator->SetNumberOfLevels(0);
m_optimizer->StopOptimization();
}
}
//------------------------------------------------------------------------------
real_t automatic_registration::get_current_metric_value() const
{
SIGHT_ASSERT("No optimization process running.", m_optimizer);
return m_optimizer->GetCurrentMetricValue();
}
//------------------------------------------------------------------------------
const optimizer_t::ParametersType& automatic_registration::get_current_parameters() const
{
SIGHT_ASSERT("No optimization process running.", m_optimizer);
return m_optimizer->GetCurrentPosition();
}
//------------------------------------------------------------------------------
real_t automatic_registration::get_relaxation_factor() const
{
SIGHT_ASSERT("No optimization process running.", m_optimizer);
return m_optimizer->GetRelaxationFactor();
}
//------------------------------------------------------------------------------
real_t automatic_registration::get_learning_rate() const
{
SIGHT_ASSERT("No optimization process running.", m_optimizer);
return m_optimizer->GetLearningRate();
}
//------------------------------------------------------------------------------
real_t automatic_registration::get_gradient_magnitude_tolerance() const
{
SIGHT_ASSERT("No optimization process running.", m_optimizer);
return m_optimizer->GetGradientMagnitudeTolerance();
}
//------------------------------------------------------------------------------
itk::SizeValueType automatic_registration::get_current_iteration() const
{
SIGHT_ASSERT("No optimization process running.", m_optimizer);
return m_optimizer->GetCurrentIteration();
}
//------------------------------------------------------------------------------
itk::SizeValueType filter::image::automatic_registration::get_current_level() const
{
SIGHT_ASSERT("No registration process running.", m_registrator);
return m_registrator->GetCurrentLevel();
}
//------------------------------------------------------------------------------
void automatic_registration::get_current_matrix(data::matrix4& _trf) const
{
SIGHT_ASSERT("No registration process running.", m_registrator);
const auto* itk_matrix = m_registrator->GetTransform();
convert_from_eigen_matrix(itk_matrix, _trf);
}
//------------------------------------------------------------------------------
void automatic_registration::convert_from_eigen_matrix(const transform_t* _itk_mat, data::matrix4& _f4s_mat) const
{
itk::Matrix<real_t, 3, 3> rigid_mat = _itk_mat->GetMatrix();
itk::Vector<real_t, 3> offset = _itk_mat->GetOffset();
if(m_invert)
{
rigid_mat = itk::Matrix<real_t, 3, 3>(_itk_mat->GetMatrix().GetTranspose());
offset = -(rigid_mat * offset);
}
// Convert itk::RigidTransform to f4s matrix.
for(std::uint8_t i = 0 ; i < 3 ; ++i)
{
_f4s_mat(i, 3) = offset[i];
for(std::uint8_t j = 0 ; j < 3 ; ++j)
{
_f4s_mat(i, j) = rigid_mat(i, j);
}
}
}
//------------------------------------------------------------------------------
void perform_automatic_registration(
const data::image& _target,
const data::image& _reference,
data::matrix4& _transform,
const registration_params_t& _params
)
{
// Create a copy of multi_resolution_parameters without empty values
multi_resolution_parameters_t multi_resolution_parameters(_params.multi_resolution_parameters.size());
using param_pair_t = multi_resolution_parameters_t::value_type;
// NOLINTNEXTLINE(modernize-use-ranges)
auto last_elt = std::remove_copy_if(
_params.multi_resolution_parameters.begin(),
_params.multi_resolution_parameters.end(),
multi_resolution_parameters.begin(),
[](const param_pair_t& _v){return _v.first == 0;});
multi_resolution_parameters.erase(last_elt, multi_resolution_parameters.end());
automatic_registration registrator;
std::fstream reg_log;
if(_params.enable_logging)
{
std::stringstream file_name_stream;
const std::time_t system_time = std::time(nullptr);
file_name_stream << "registration_"
<< std::put_time(std::localtime(&system_time), "%Y-%m-%d_%H-%M-%S") << ".csv";
reg_log.open(file_name_stream.str(), std::ios_base::out);
reg_log << "'Timestamp',"
<< "'Current level',"
<< "'Current iteration',"
<< "'Shrink',"
<< "'Sigma',"
<< "'Current metric value',"
<< "'Current parameters',"
<< "'Current transform',"
<< "'Relaxation factor',"
<< "'Learning rate',"
<< "'Gradient magnitude tolerance',"
<< "'Minimum step size',"
<< "'Maximum number of iterations',"
<< "'Sampling rate',"
<< "'Number of levels'"
<< std::endl;
}
std::chrono::time_point<std::chrono::system_clock> reg_start_time;
std::size_t i = 0;
automatic_registration::iteration_callback_t iteration_callback =
[&]()
{
const itk::SizeValueType current_iteration = registrator.get_current_iteration();
const itk::SizeValueType current_level = registrator.get_current_level();
const float progress = float(i++) / float(_params.max_iterations * multi_resolution_parameters.size());
const std::string msg = "Number of iterations : " + std::to_string(i) + " Current level : "
+ std::to_string(current_level);
SIGHT_INFO(progress << "% " << msg);
registrator.get_current_matrix(_transform);
if(_params.enable_logging)
{
std::stringstream transform_stream;
for(std::uint8_t j = 0 ; j < 16 ; ++j)
{
transform_stream << _transform[j];
if(j != 15)
{
transform_stream << ";";
}
}
const std::chrono::time_point<std::chrono::system_clock> now =
std::chrono::system_clock::now();
const auto duration = now - reg_start_time;
reg_log << "'" << std::chrono::duration_cast<std::chrono::milliseconds>(duration).count() << "',"
<< "'" << current_level << "',"
<< "'" << current_iteration << "',"
<< "'" << multi_resolution_parameters[current_level].first << "',"
<< "'" << multi_resolution_parameters[current_level].second << "',"
<< "'" << registrator.get_current_metric_value() << "',"
<< "'" << registrator.get_current_parameters() << "',"
<< "'" << transform_stream.str() << "',"
<< "'" << registrator.get_relaxation_factor() << "',"
<< "'" << registrator.get_learning_rate() << "',"
<< "'" << registrator.get_gradient_magnitude_tolerance() << "',"
<< "'" << _params.min_step << "',"
<< "'" << _params.max_iterations << "',"
<< "'" << _params.sampling_percentage << "',"
<< "'" << multi_resolution_parameters.size() << "'"
<< std::endl;
reg_log.flush(); // Flush, just to be sure.
}
};
try
{
registrator.register_image(
_target,
_reference,
_transform,
_params.metric,
multi_resolution_parameters,
_params.sampling_percentage,
_params.min_step,
_params.max_iterations,
iteration_callback
);
}
catch(itk::ExceptionObject& e)
{
SIGHT_ERROR("[ITK EXCEPTION]" << e.GetDescription());
}
}
} // namespace sight::filter::image
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