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# supported distribution names are: Normal, LogNormal, Uniform, Beta
# Modalities are: Mammo, Tomo, MRI, CT
Scenario:
# use true for variable spreading
# spread: true
spread: false
iterations: 1
# random generator behavior:
# random, fixed, increasing
generator: fixed
# initial seed unless using generator: random
seed: 1
# n cases to simulate
cases: 1000
# Used for all modalities except for CT:
# ref.age proportion biop specs (first diameter must be 0)
# Lungcancer costs: configured at Modalities: CT: costs:
Costs:
biop: 176
diameters: 0: 6438 20: 7128 50: 7701
Discount: # breast lung
proportion: 0 .04
age: 50
BreastDensities:
# bi-rad: a b c d
ageGroup: 0 - 40: .05 .30 .48 .17
ageGroup: 40 - 50: .06 .34 .47 .13
ageGroup: 50 - 60: .08 .50 .37 .05
ageGroup: 60 - 70: .15 .53 .29 .03
ageGroup: 70 - * : .18 .54 .26 .02
Modalities:
CT:
# screening diagnosis M0 M1 (M0, M1: Table S3)
costs: 176 1908 37909 56556
dose: 1
# diam. value (must be integral 0..100 or -1)
sensitivity: 0 - 3: 0
sensitivity: 3 - 5: -1 # formula: (.5 * diam - 1.5) * 100
sensitivity: 5 - *: 100
# mean stddev dist
specificity: 99.2 .076 Normal
Mammo:
costs: 64
# bi-rad: a b c d
dose: 3 3 3 3
m: .136 .136 .136 .136
# ageGroup
specificity: 0 - 40: .961 40 - *: .965
# 1 2 3 4
beta: -4.38 .49 -1.34 -7.18
systematicError: 0.1
Tomo:
costs: 64
# bi-rad: a b c d
dose: 3 3 3 3
sensitivity: .87 .84 .73 .65
# ageGroup
specificity: 0 - 40: .961 40 - *: .965
MRI:
costs: 280
sensitivity: .94
specificity: .95
Screening:
# round: age space separated modalities.
# subsequent ages must exceed the last age by at least 1
# with lung cancer simulations only CT can be specified,
# with breast cancer simulations CT cannot be specified,
round: 50 CT
round: 52 CT
round: 54 CT
round: 56 CT
round: 58 CT
round: 60 CT
round: 62 CT
round: 64 CT
round: 66 CT
round: 68 CT
round: 70 CT
round: 72 CT
round: 74 CT
# proportion:
attendanceRate: .8
Tumor:
Beir7:
# eta beta spread dist.
breast: -2.0 0.51 0.32 Normal
# Beta-distribution parameters:
# LC: eta beta dist constant factor aParam bParam
male: -1.4 .32 Beta .234091 1.72727 2.664237 5.184883
female: -1.4 1.40 Beta .744828 .818966 3.366115 4.813548
Growth:
# breast lung
start: 5 3
#selfDetect: # stdev mean spread dist
breast: .70 2.92 .084 Normal
lung: .014 3.037 .061 Normal
DoublingTime:
# stdev mean spread dist.
ageGroup: 1 - 50: .61 4.38 .43 Normal
ageGroup: 50 - 70: .26 5.06 .17 Normal
ageGroup: 70 - * : .45 5.24 .23 Normal
# all ages stdev mean spread dist.
lung: .21 4.59 .74 Normal
Incidence:
Male:
# value spread distr.
lifetimeRisk: .22 .005 Normal
meanAge: 72.48 1.08 Normal
stdDev: 9.28 1.62 Normal
Female:
# value spread distr.
lifetimeRisk: .20 .004 Normal
meanAge: 69.62 1.49 Normal
stdDev: 9.73 1.83 Normal
Breast:
probability: 1
# value spread distr.
lifetimeRisk: .226 .0053 Normal
meanAge: 72.9 .552 Normal
stdDev: 21.1
BRCA1:
probability: 0
# value spread distr.
lifetimeRisk: .96
meanAge: 53.9
stdDev: 16.51
BRCA2:
probability: 0
# value spread distr.
lifetimeRisk: .96
meanAge: 53.9
stdDev: 16.51
Survival:
# value spread dist:
type: a .00004475 .000004392 Normal
type: b 1.85867 .0420 Normal
type: c -.271 .0101 Normal
type: d 2.0167 .0366 Normal
# table S4: 4 columns per a..d parameter
# lungX: X is table S4's column index
lung0: a .00143 .00095 Normal
lung0: b 1.84559 .33748 Normal
lung0: c -.22794 .07823 Normal
lung0: d 1.06799 .16226 Normal
lung1: a .01530 .00381 Normal
lung1: b 1.69434 .10979 Normal
lung1: c -.19358 .02105 Normal
lung1: d .66690 .03869 Normal
lung2: a .78600 .29815 Normal
lung2: b .69791 .05425 Normal
lung2: c .0 .0 Normal
lung2: d .0 .0 Normal
lung3: a 1.25148 .32305 Normal
lung3: b .77852 .34149 Normal
lung3: c .0 .0 Normal
lung3: d .0 .0 Normal
S3:
# T-row range N0,M0 N1-3,M0 N1-3,M1a-b N0-3M1c
prob: 0 - 11: .756 .157 .048 .039 # T1a,b
prob: 11 - 21: .703 .197 .055 .045 # T1b
prob: 21 - 31: .559 .267 .095 .078 # T1c
prob: 31 - 51: .345 .351 .167 .137 # T2a,b
prob: 51 - 71: .196 .408 .218 .178 # T3
prob: 71 - * : .187 .347 .256 .210 # T4
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