1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
|
CLUSTAL FORMAT for T-COFFEE Version_4.38 [http://www.tcoffee.org], CPU=18.85 sec, SCORE=94, Nseq=19, Len=334
sp|O35205|GRAK_MOUSE MRFSS-----W---A-LVSLVAGVY----------------------MSSECFHTEIIGG
sp|Q7YRZ7|GRAA_BOVIN MNIPFPFSFPP---AICLLLIPGVF-------------------------PVSCEGIIGG
sp|P08884|GRAE_MOUSE M-------------P-PVLILLTLL----------------------LPLGAGAEEIIGG
sp|Q06606|GRZ2_RAT M-------------F-LFLFFLVAI----------------------LPVNTEGGEIIWG
sp|P21844|MCPT5_MOUSE M---------H---L-LTLHLLLLL----------------------LGSSTKAGEIIGG
sp|P03953|CFAD_MOUSE MHSSV-----Y---F-VALVILGAA----------------------VCAAQPRGRILGG
sp|P00773|ELA1_RAT ML-----RFLVF---ASLVLYGHST----------------------QDFPETNARVVGG
sp|Q00871|CTRB1_PENVA MI-----GKLSLLLVCVAVASGNPA-----AGKPWHWKSPKPLVDP-RIHVNATPRIVGG
sp|P08246|ELNE_HUMAN MTLGR--RLACL---FLACVLPALL----------------------LGGTALASEIVGG
sp|P20160|CAP7_HUMAN MT-----RLTVL---ALLAGLLASS----------------------RAGSSPLLDIVGG
sp|P80015|CAP7_PIG --------------------------------------------------------IVGG
sp|Q03238|GRAM_RAT L--------------LLLLALKTLW----------------------AVGNRFEAQIIGG
sp|P00757|KLKB4_MOUSE M---------W---F-LILFLALSL-------------------GGIDAAPPVQ----SQ
sp|Q6H321|KLK2_HORSE M---------W---F-LVLCLDLSL-------------------GETGALPPIQSRIIGG
sp|Q91VE3|KLK7_MOUSE M-------GVW---L-LSLITVLLS-------------------LAL-ETAGQGERIIDG
sp|Q9Y5K2|KLK4_HUMAN MATA-GNPWGW---F-LG-YLILGV-------------------AGS-LVSGSCSQIING
sp|P29786|TRY3_AEDAE M-N----QFLFVSF-CALLDSAKV-----SAA------------------TLSSGRIVGG
sp|P35037|TRY3_ANOGA MIS----NKIAIL--LAVLVVAVAC-AQARVAQQHRSVQALPRFLP-RPKYDVGHRIVGG
sp|P07338|CTRB1_RAT MAFLW----LVS---CFALVGATFGCGVPTI--Q--------------PVLTGLSRIVNG
sp|O35205|GRAK_MOUSE REVQPHSRPFMASIQY----RSKHICGGVLIHPQWVLTAAHCYSWFPRGHSPTVVLGAHS
sp|Q7YRZ7|GRAA_BOVIN NEVAPHTRRYMALIK------GLKLCAGALIKENWVLTAAHCDLK----GNPQVILGAHS
sp|P08884|GRAE_MOUSE HVVKPHSRPYMAFVKSVDIEGNRRYCGGFLVQDDFVLTAAHCRN-----RTMTVTLGAHN
sp|Q06606|GRZ2_RAT TESKPHSRPYMAFIKFYDSNSEPHHCGGFLVAKDIVMTAAHCNG-----RNIKVTLGAHN
sp|P21844|MCPT5_MOUSE TECIPHSRPYMAYLEIVTSENYLSACSGFLIRRNFVLTAAHCAG-----RSITVLLGAHN
sp|P03953|CFAD_MOUSE QEAAAHARPYMASVQV----NGTHVCGGTLLDEQWVLSAAHCMDGVTDDDSVQVLLGAHS
sp|P00773|ELA1_RAT AEARRNSWPSQISLQYLSGGSWYHTCGGTLIRRNWVMTAAHCVSSQ---MTFRVVVGDHN
sp|Q00871|CTRB1_PENVA VEATPHSWPHQAALFID----DMYFCGGSLISSEWVLTAAHCMDGA---GFVEVVLGAHN
sp|P08246|ELNE_HUMAN RRARPHAWPFMVSLQLR----GGHFCGATLIAPNFVMSAAHCVANV-NVRAVRVVLGAHN
sp|P20160|CAP7_HUMAN RKARPRQFPFLASIQNQ----GRHFCGGALIHARFVMTAASCFQSQ-NPGVSTVVLGAYD
sp|P80015|CAP7_PIG RRAQPQEFPFLASIQKQ----GRPFCAGALVHPRFVLTAASCFRGK-NSGSASVVLGAYD
sp|Q03238|GRAM_RAT REAVPHSRPYMVSLQNT----KSHMCGGVLVHQKWVLTAAHCLSE--PLQQLKLVFGLHS
sp|P00757|KLKB4_MOUSE V-DCENSQPWHVAVYR----FNKYQCGGVLLDRNWVLTAAHCYN-----DKYQVWLGKNN
sp|Q6H321|KLK2_HORSE WECEKHSKPWQVAVYH----QGHFQCGGVLVHPQWVLTAAHCMS-----DDYQIWLGRHN
sp|Q91VE3|KLK7_MOUSE YKCKEGSHPWQVALLK----GNQLHCGGVLVDKYWVLTAAHCKM-----GQYQVQLGSDK
sp|Q9Y5K2|KLK4_HUMAN EDCSPHSQPWQAALVM----ENELFCSGVLVHPQWVLSAAHCFQ-----NSYTIGLGLHS
sp|P29786|TRY3_AEDAE FQIDIAEVPHQVSLQRS----GRHFCGGSIISPRWVLTRAHCTTNT-DPAAYTIRAGSTD
sp|P35037|TRY3_ANOGA FEIDVSETPYQVSLQYF----NSHRCGGSVLNSKWILTAAHCTVNL-QPSSLAVRLGSSR
sp|P07338|CTRB1_RAT EDAIPGSWPWQVSLQDK---TGFHFCGGSLISEDWVVTAAHCGVKT----SDVVVAGEFD
: *.. :: ::: * * : *
sp|O35205|GRAK_MOUSE LSKN-EP-MKQTFEIKKFIPFSRLQSGSA-----------SHDIMLIKLRTAAELNKNVQ
sp|Q7YRZ7|GRAA_BOVIN TSHK-EK-LDQVFSIKKAIPYPCFDPQTF-----------EGDLQLLQLEGKATMTKAVG
sp|P08884|GRAE_MOUSE IKAK-EE-TQQIIPVAKAIPHPDYNATAF-----------FSDIMLLKLESKAKRTKAVR
sp|Q06606|GRZ2_RAT IKKQ-E--NTQVISVVKAKPHENYDRDSH-----------FNDIMLLKLERKAQLNGVVK
sp|P21844|MCPT5_MOUSE KTSK-ED-TWQKLEVEKQFLHPKYDENLV-----------VHDIMLLKLKEKAKLTLGVG
sp|P03953|CFAD_MOUSE LSAP-EP-YKRWYDVQSVVPHPGSRPDSL-----------EDDLILFKLSQNASLGPHVR
sp|P00773|ELA1_RAT LSQN-DG-TEQYVSVQKIMVHPTWNSNNVAA---------GYDIALLRLAQSVTLNNYVQ
sp|Q00871|CTRB1_PENVA IRQN-EA-SQVSITSTDFFTHENWNSWLL-----------TNDIALIRLPSPVSLNSNIK
sp|P08246|ELNE_HUMAN LSRR-EP-TRQVFAVQR-IFENGYDPVNL-----------LNDIVILQLNGSATINANVQ
sp|P20160|CAP7_HUMAN LRRR-ERQSRQTFSISS-MSENGYDPQQN-----------LNDLMLLQLDREANLTSSVT
sp|P80015|CAP7_PIG LRQQ-EQ-SRQTFSIRS-ISQNGYDPRQN-----------LNDVLLLQLDREARLTPSVA
sp|Q03238|GRAM_RAT LHDP-QD-PGLTFYIKQAIKHPGYNL-KY-----------ENDLALLKLDGRVKPSKNVK
sp|P00757|KLKB4_MOUSE FLED-EP-SDQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLSKPADITDVVK
sp|Q6H321|KLK2_HORSE LSED-ED-TAQFHQVSDSFLDPQFDLSLLKKKYLRPYDDISHDLMLLRLAQPARITDAVK
sp|Q91VE3|KLK7_MOUSE IGD---Q-SAQKIKATKSFRHPGYSTKT-----------HVNDIMLVRLDEPVKMSSKVE
sp|Q9Y5K2|KLK4_HUMAN LEADQEP-GSQMVEASLSVRHPEYNRPL-----------LANDLMLIKLDESVSESDTIR
sp|P29786|TRY3_AEDAE RT-----NGGIIVKVKSVIPHPQYNGDTY-----------NYDFSLLELDESIGFSRSIE
sp|P35037|TRY3_ANOGA HA-----SGGTVVRVARVLEHPNYDDSTI-----------DYDFSLMELESELTFSDVVQ
sp|P07338|CTRB1_RAT QGSD-EE-NIQVLKIAQVFKNPKFNMFTV-----------RNDITLLKLATPAQFSETVS
*. :..* :
sp|O35205|GRAK_MOUSE LLHLGSKN--YLRDGTKCQVTGWGTTKPDLLTASDTLREVTVTIISRKRCNSQSYYNHKP
sp|Q7YRZ7|GRAA_BOVIN ILQLPRTE-DDVKPHTKCHVAGWGSTKKDACQMSNALREANVTVIDRKICNDAQHYNFNP
sp|P08884|GRAE_MOUSE PLKLPRPN-ARVKPGDVCSVAGWGSRSINDTKASARLREAQLVIQEDEECKKRF----RH
sp|Q06606|GRZ2_RAT TIALPRSQ-DWVKPGQVCTVAGWGRLANC--TSSNTLQEVNLEVQKGQKCQDMS----ED
sp|P21844|MCPT5_MOUSE TLPLSANF-NFIPPGRMCRAVGWGRTNVNE-PASDTLQEVKMRLQEPQACKHF-----TS
sp|P03953|CFAD_MOUSE PLPLQYED-KEVEPGTLCDVAGWGVVTHA-GRRPDVLHQLRVSIMNRTTCNLRTYH--DG
sp|P00773|ELA1_RAT LAVLPQEG-TILANNNPCYITGWGRTRTN-GQLSQTLQQAYLPSVDYSICSSSSYW--GS
sp|Q00871|CTRB1_PENVA TVKLPSSD-V--SVGTTVTPTGWGRPSDSASGISDVLRQVNVPVMTNADCDSVY-----G
sp|P08246|ELNE_HUMAN VAQLPAQG-RRLGNGVQCLAMGWGLLGRN-RGIASVLQELNVTVVT-SLCRR--------
sp|P20160|CAP7_HUMAN ILPLPLQN-ATVEAGTRCQVAGWGSQRSG-GRLSRFPRFVNVTVTPEDQCRP--------
sp|P80015|CAP7_PIG LVPLPPQN-ATVEAGTNCQVAGWGTQRLR-RLFSRFPRVLNVTVTS-NPCLP--------
sp|Q03238|GRAM_RAT PLALPRKPRDKPAEGSRCSTAGWGITHQR-GQLAKSLQELDLRLLDTRMCNNSRFW--NG
sp|P00757|KLKB4_MOUSE PITLPTEE---PKLGSTCLASGWGSTTPIKFKYPDDLQCVNLKLLPNEDCDKAH----EM
sp|Q6H321|KLK2_HORSE ILDLPTQE---PKLGSTCYTSGWGLISTFTNRGSGTLQCVELRLQSNEKCARAY----PE
sp|Q91VE3|KLK7_MOUSE AVQLPEHC---EPPGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKVY----KD
sp|Q9Y5K2|KLK4_HUMAN SISIASQC---PTAGNSCLVSGWGLLANG--RMPTVLQCVNVSVVSEEVCSKLY----DP
sp|P29786|TRY3_AEDAE AIALPDAS-ETVADGAMCTVSGWGDTKNV-FEMNTLLRAVNVPSYNQAECAAALVNV--V
sp|P35037|TRY3_ANOGA PVSLPDQD-EAVEDGTMTIVSGWGNTQSA-AESNAILRAANVPTVNQKECTIAYSSS--G
sp|P07338|CTRB1_RAT AVCLPNVD-DDFPPGTVCATTGWGKTKYNALKTPEKLQQAALPIVSEADCKKSW----GS
: *** : *
sp|O35205|GRAK_MOUSE VITKDMICAGDARGQKDSCKGDSGGPLICK--G--IFHALVSQGYK--CGIAKKPGIYTL
sp|Q7YRZ7|GRAA_BOVIN VIDLSMICAGGRKGEDDSCEGDSGSPLICD--N--VFRGVTSFGK---CGNPQKPGIYIL
sp|P08884|GRAE_MOUSE YTETTEICAGDLKKIKTPFKGDSGGPLVCD--N--KAYGLLAYAKN----RTISSGVFTK
sp|Q06606|GRZ2_RAT YNDSIQLCVGNPSEGKATGKGDSGGPFVCD--G--VAQGIVSYRLC----TGTLPRVFTR
sp|P21844|MCPT5_MOUSE FRHNSQLCVGNPKKMQNVYKGDSGGPLLCA--G--IAQGIASYVHR----NAKPPAVFTR
sp|P03953|CFAD_MOUSE VVTINMMCAE--SNRRDTCRGDSGSPLVCG--D--AVEGVVTWGSR-VCGNGKKPGVYTR
sp|P00773|ELA1_RAT TVKTTMVCAGG-DGVRSGCQGDSGGPLHCLVNGQYSVHGVTSFVSSMGCNVSKKPTVFTR
sp|Q00871|CTRB1_PENVA IVGDGVVCIDG-TGGKSTCNGDSGGPLNLN--G--MTYGITSFGSS-AGCEKGYPAAFTR
sp|P08246|ELNE_HUMAN ----SNVCTLVRGRQAGVCFGDSGSPLVCN--G--LIHGIASFVRG-GCASGLYPDAFAP
sp|P20160|CAP7_HUMAN ----NNVCTGVLTRRGGICNGDGGTPLVCE--G--LAHGVASFSLG-PCG--RGPDFFTR
sp|P80015|CAP7_PIG ----RDMCIGVFSRRGRISQGDRGTPLVCN--G--LAQGVASFLRR-RFR--RSSGFFTR
sp|Q03238|GRAM_RAT VLTDSMLCLKAGAKGQAPCKGDSGGPLVCGK-G--KVDGILSFSSK-NCTDIFKPTVATA
sp|P00757|KLKB4_MOUSE KVTDAMLCAGEMDGGSYTCEHDSGGPLICD--G--ILQGITSWGPE-PCGEPTEPSVYTK
sp|Q6H321|KLK2_HORSE KMTEFVLCATHRDDSGSICLGDSGGALICD--G--VFQGITSWGYS-ECADFNDNFVFTK
sp|Q91VE3|KLK7_MOUSE LLGKTMLCAGIPDSKTNTCNGDSGGPLVCN--D--TLQGLVSWGTY-PCGQPNDPGVYTQ
sp|Q9Y5K2|KLK4_HUMAN LYHPSMFCAGGGQDQKDSCNGDSGGPLICN--G--YLQGLVSFGKA-PCGQVGVPGVYTN
sp|P29786|TRY3_AEDAE PVTEQMICAGYAAGGKDSCQGDSGGPLVSG--D--KLVGVVSWGKG--CALPNLPGVYAR
sp|P35037|TRY3_ANOGA GITDRMLCAGYKRGGKDACQGDSGGPLVVD--G--KLVGVVSWGFG--CAMPGYPGVYAR
sp|P07338|CTRB1_RAT KITDVMTCAG--ASGVSSCMGDSGGPLVCQKDGVWTLAGIVSWGSG-VCST-STPAVYSR
* * * .: . .: :
sp|O35205|GRAK_MOUSE LTKKYQTWIKSKLAPSR---------------AH
sp|Q7YRZ7|GRAA_BOVIN LTKKHLNWIKKTIAGA-----------------I
sp|P08884|GRAE_MOUSE IV-HFLPWISRNMKLL------------------
sp|Q06606|GRZ2_RAT IS-SFIPWIQKTMKVLQ---------------QS
sp|P21844|MCPT5_MOUSE IS-HYRPWINKILREN------------------
sp|P03953|CFAD_MOUSE VS-SYRMWIENITNGNM---------------TS
sp|P00773|ELA1_RAT VS-AYISWMNNVIAY------------------T
sp|Q00871|CTRB1_PENVA VY-YYLDWIQQKTGVT-----------------P
sp|P08246|ELNE_HUMAN VA-QFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
sp|P20160|CAP7_HUMAN VA-LFRDWIDGVLNNPGPG-------------PA
sp|P80015|CAP7_PIG VA-LFRNWIDSVLNNP-----------------P
sp|Q03238|GRAM_RAT VA-PYSSWIRKVIGRWSPQP------------LT
sp|P00757|KLKB4_MOUSE LI-KFSSWIRETMANN-----------------P
sp|Q6H321|KLK2_HORSE VM-PHLKWIKETIEKN-----------------S
sp|Q91VE3|KLK7_MOUSE VC-KYKRWVMETMKTH-----------------R
sp|Q9Y5K2|KLK4_HUMAN LC-KFTEWIEKTVQA------------------S
sp|P29786|TRY3_AEDAE VS-TVRQWIREVSEV-------------------
sp|P35037|TRY3_ANOGA VA-VVRDWVRENSGA-------------------
sp|P07338|CTRB1_RAT VT-ALMPWVQQILEAN------------------
: *:
|
