1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330
|
/* The MIT License
Copyright (c) 2015 Adrian Tan <atks@umich.edu>
Permission is hereby granted, free of charge, to any person obtaining a copy
of this software and associated documentation files (the "Software"), to deal
in the Software without restriction, including without limitation the rights
to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
copies of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:
The above copyright notice and this permission notice shall be included in
all copies or substantial portions of the Software.
THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
THE SOFTWARE.
*/
#include "circular_buffer.h"
/**
* Constructor.
*
* @k - size of pileup is 2^k
*/
CircularBuffer::CircularBuffer(uint32_t k, uint32_t window_size)
{
//Buffer size is a power of 2^k.
buffer_size = 1 << k;
//this provides a cheaper way to do modulo operations for a circular array.
buffer_size_mask = (0xFFFFFFFF >> (32-k));
this->window_size = window_size;
P.resize(buffer_size);
tid = -1;
beg0 = end0 = 0;
gbeg1 = 0;
debug = 0;
};
/**
* Overloads subscript operator for accessing pileup positions.
*/
char& CircularBuffer::operator[] (const int32_t i)
{
return P[i];
}
/**
* Returns the maximum size of the pileup.
*/
uint32_t CircularBuffer::max_size()
{
return buffer_size - 1;
}
/**
* Returns the size of the pileup.
*/
uint32_t CircularBuffer::size()
{
return (end0>=beg0 ? end0-beg0 : buffer_size-(beg0-end0));
}
/**
* Checks if buffer is empty.
*/
bool CircularBuffer::is_empty()
{
return beg0==end0;
};
/**
* Set reference fasta file.
*/
void CircularBuffer::set_reference(std::string& ref_fasta_file)
{
if (ref_fasta_file!="")
{
fai = fai_load(ref_fasta_file.c_str());
if (fai==NULL)
{
fprintf(stderr, "[%s:%d %s] cannot load genome index: %s\n", __FILE__, __LINE__, __FUNCTION__, ref_fasta_file.c_str());
exit(1);
}
}
};
/**
* Set debug.
*/
void CircularBuffer::set_debug(int32_t debug)
{
this->debug = debug;
};
/**
* Sets tid.
*/
void CircularBuffer::set_tid(uint32_t tid)
{
this->tid = tid;
}
/**
* Gets tid.
*/
uint32_t CircularBuffer::get_tid()
{
return this->tid;
}
/**
* Sets chrom.
*/
void CircularBuffer::set_chrom(std::string& chrom)
{
this->chrom = chrom;
}
/**
* Gets chrom.
*/
std::string CircularBuffer::get_chrom()
{
return chrom;
}
/**
* Gets window_size.
*/
uint32_t CircularBuffer::get_window_size()
{
return window_size;
}
/**
* Converts gpos1 to index in P.
* If P is empty, initialize first position as gpos1.
*/
uint32_t CircularBuffer::g2i(uint32_t gpos1)
{
if (is_empty())
{
gbeg1 = gpos1;
return beg0;
}
else
{
if (gpos1<gbeg1)
{
fprintf(stderr, "[%s:%d %s] buffer out of extent: gpos1 %d < gbeg1 %d\n", __FILE__, __LINE__, __FUNCTION__, gpos1, gbeg1);
abort();
}
return (beg0 + (gpos1-gbeg1)) & buffer_size_mask;
}
}
/**
* Increments i by 1 circularly.
*/
uint32_t CircularBuffer::inc(uint32_t i)
{
return (i+1) & buffer_size_mask;
};
/**
* Sets gbeg1.
*/
void CircularBuffer::set_gbeg1(uint32_t gbeg1)
{
this->gbeg1 = gbeg1;
}
/**
* Gets gbeg1.
*/
uint32_t CircularBuffer::get_gbeg1()
{
return gbeg1;
}
/**
* Gets gend1.
*/
uint32_t CircularBuffer::get_gend1()
{
if (is_empty())
{
return 0;
}
else
{
return gbeg1 + diff(end0, beg0) - 1;
}
}
/**
* Sets beg0.
*/
void CircularBuffer::set_beg0(uint32_t beg0)
{
this->beg0 = beg0;
}
/**
* Sets end0.
*/
void CircularBuffer::set_end0(uint32_t end0)
{
this->end0 = end0;
}
/**
* Gets the index of the first element.
*/
uint32_t CircularBuffer::begin()
{
return beg0;
}
/**
* Gets the index of the last element.
*/
uint32_t CircularBuffer::end()
{
return end0;
}
/**
* Returns the difference between 2 buffer positions
*/
uint32_t CircularBuffer::diff(uint32_t i, uint32_t j)
{
return (i>=j ? i-j : buffer_size-(j-i));
};
/**
* Increments beg0 by 1.
*/
void CircularBuffer::inc_beg0()
{
beg0 = (beg0+1) & buffer_size_mask;
};
/**
* Increments end0 by 1.
*/
void CircularBuffer::inc_end0()
{
end0 = (end0+1) & buffer_size_mask;
};
/**
* Increments index i by j cyclically.
*/
uint32_t CircularBuffer::inc(uint32_t i, uint32_t j)
{
return (i+j) & buffer_size_mask;
};
/**
* Get a base.
*/
char CircularBuffer::fetch_base(std::string& chrom, uint32_t& pos1)
{
int ref_len = 0;
char *refseq = faidx_fetch_uc_seq(fai, chrom.c_str(), pos1-1, pos1-1, &ref_len);
if (!refseq)
{
fprintf(stderr, "[%s:%d %s] failure to extract base from fasta file: %s:%d: >\n", __FILE__, __LINE__, __FUNCTION__, chrom.c_str(), pos1-1);
exit(1);
}
char base = refseq[0];
free(refseq);
return base;
};
///**
// * Get a sequence. User have to free the char* returned.
// */
//char* CircularBuffer::get_sequence(std::string& chrom, uint32_t pos1, uint32_t len)
//{
// int ref_len = 0;
// char* seq = faidx_fetch_uc_seq(fai, chrom.c_str(), pos1-1, pos1+len-2, &ref_len);
// if (!seq || ref_len!=len)
// {
// fprintf(stderr, "[%s:%d %s] failure to extract sequence from fasta file: %s:%d: >\n", __FILE__, __LINE__, __FUNCTION__, chrom.c_str(), pos1-1);
// exit(1);
// }
//
// return seq;
//};
/**
* Print pileup state.
*/
void CircularBuffer::print_state()
{
std::cerr << "******************" << "\n";
std::cerr << "gindex : " << gbeg1 << "-" << get_gend1() << "\n";
std::cerr << "index : " << beg0 << "-" << end0 << " (" << size() << ")\n";
std::cerr << "******************" << "\n";
uint32_t k = 0;
for (uint32_t i=beg0; i!=end0; i=inc(i))
{
//P[i].print(gbeg1+k);
++k;
}
std::cerr << "******************" << "\n";
}
/**
* Print pileup state extent.
*/
void CircularBuffer::print_state_extent()
{
std::cerr << "******************" << "\n";
std::cerr << "gindex : " << gbeg1 << "-" << get_gend1() << "\n";
std::cerr << "index : " << beg0 << "-" << end0 << " (" << size() << ")\n";
std::cerr << "******************" << "\n";
}
|