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#include <string>
#include "edit_distance.h"
using namespace std;
int ** F;
char ** traceback;
/* Description of edit_distance algo
* given q_seq and db_seq it return alignment between these 2 sequence
*
* we have qlen*dlen edit_distance matrix.
* 0th row is intitalized with 0
* 0th columng is initialized with their row number
*
* [i,j] = min ( [i-1][j]+1 , [i][j-1]+1 , [i-1][j-1] + {0 if db[i] == query[j] , 1 otherwise }
* this is very similar to Needlman+Wunsch global alignment alog.
*
* traceBack matrix of same size is also created. depending upon which of three are minimum traceback is initialized
*
* once we have traceback. we look at last row and start building alignment from lowest column in last row.
*
* for example if last row is 7,6,6,5,4,3,2,4,5. then we start building alignment from 3.
* reason we do this is because dblen is more then qlen ( to adjust gaps) so if we have better score some where in
* last row means last few character of dbseq can be ignored
*
* once we have starting location we follow traceback matrix and start building the alignment.
*
* this way alignment is built in reverse order need to modify the order.
*
*
*
*/
void edit_distance_init() {
int i;
int L1 = 99;
int L2 = 99;
// Dynamic programming matrix
F = (int **) malloc(sizeof(int *) * (L2 + 1));
for (i = 0; i <= L2; i++)
F[i] = (int *) malloc(sizeof(int) * (L1 + 1));
// Traceback matrix
traceback = (char **) malloc(sizeof(char *) * (L2 + 1));
for (i = 0; i <= L2; i++)
traceback[i] = (char *) malloc(sizeof(char) * (L1 + 1));
}
scoreinfo edit_distance(char *q_seq, char *db_seq, int q_len, int db_len,
char *align_query, char *align_db, int prm) {
int gap_penalty = obj_score_mat.gap_penalty; /* gap penalty */
// can not assume that q_seq and db_seq are null terminated
int L1 = db_len; //strlen(db_seq);
int L2 = q_len; //strlen(q_seq);
int i;
#if EDIT_DEBUG
printf("db_len : %d , query_len : %d \n",L1,L2);
#endif
//printf("inside nw() %s %s ",db_seq,q_seq);
// Initialize traceback and F matrix (fill in first row and column)
matrix_init(F, traceback, L1, L2, gap_penalty);
// Create alignment
scoreinfo ret = edit_distance_align(F, traceback, q_seq, db_seq, q_len,
db_len, align_query, align_db, gap_penalty);
//print_score(ret);
#if EDIT_DEBUG
cout << "Length after alignment: " << ret.align_len << endl;
#endif
if (prm) {
printf("\nEdit Distance matrix:\n\n");
print_matrix(F, db_seq, q_seq, db_len, q_len);
printf("\nTraceback matrix: \n\n");
print_traceback(traceback, db_seq, q_seq, db_len, q_len);
printf("\n");
}
//for( int i = 0; i <= L2; i++ ) delete F[ i ];
//delete [] F;
//for( int i = 0; i <= L2; i++ ) delete traceback[ i ];
//delete [] traceback;
return ret;
}
void matrix_init(int ** F, char ** traceback, int L1, int L2, int d) {
F[0][0] = 0;
traceback[0][0] = 'n';
int i = 0, j = 0;
// initialize 1st row to 0
for (j = 1; j <= L1; j++) {
F[0][j] = 0;
traceback[0][j] = '-';
}
for (i = 1; i <= L2; i++) {
F[i][0] = i;
traceback[i][0] = '|';
}
}
/*
* Logic of edit_distance Alignment.
* given two string q_seq and db_seq. we perform edit_distance based alignment.
*
* matrix F is populated using dynamic programming appraoch.
*
*
*
*
*/
scoreinfo edit_distance_align(
// Needleman-Wunsch algorithm
int ** F, char ** traceback, char * q_seq, char * db_seq, int q_len,
int db_len, char *query_align, char *db_align, int gap_penalty // Gap penalty
) {
//char * db_align = tmp_seq_1_al;
//char * query_align = tmp_seq_2_al;
int k = 0, x = 0, y = 0;
int fU, fD, fL;
char ptr; //, nuc ;
int i = 0, j = 0;
scoreinfo ret = { 0, 0, 0, 0, 0, 0, 0 };
int L1 = db_len;
int L2 = q_len;
int s;
for (i = 1; i <= L2; i++) {
for (j = 1; j <= L1; j++) {
//nuc = seq_1[ j-1 ] ;
if (db_seq[j - 1] == q_seq[i - 1]) {
s = 0;
} else {
s = 1;
}
fU = F[i - 1][j] + 1;
fD = F[i - 1][j - 1] + s;
fL = F[i][j - 1] + 1;
F[i][j] = min(fU, fD, fL, &ptr);
traceback[i][j] = ptr;
}
}
i--;
j--;
// instead of starting look back from [qlen][dlen] start from minimum in [qlen] row.
int loc_j = j;
ret.score = F[i][j];
for (int jj = j; jj >= 0; jj--) {
if (ret.score > F[i][jj]) { //TODO : we need to check if we should move when min score is equal to score on left . moving when equal might put more gap.
ret.score = F[i][jj];
loc_j = jj;
}
}
#ifdef EDIT_DEBUG
printf("Best score %d found at [%d][%d]",ret.score,i,loc_j);
#endif
j = loc_j;
//print_traceback(traceback,seq_1,seq_2);
int kk = 0;
while (i > 0 || j > 0) {
//int tmp_db = strlen(db_align),tmp_q = strlen(query_align),tmp_i=i,tmp_j = j;
char tmp_trace = traceback[i][j];
switch (traceback[i][j]) {
case '|':
db_align[k] = '-';
query_align[k] = q_seq[i - 1]; // db_align is initialized to 0 so direct assignment can be made here
i--;
ret.dgap++;
break;
case '\\':
db_align[k] = db_seq[j - 1];
query_align[k] = q_seq[i - 1];
if (db_seq[j - 1] != q_seq[i - 1])
ret.mm++;
else
ret.n_iden++;
i--;
j--;
break;
case '-':
db_align[k] = db_seq[j - 1];
query_align[k] = '-';
ret.qgap++;
j--;
}
k++;
}
ret.align_len = k;
//print_score(ret);
// check if gap occur at any end of query_align ( qstring ) and if it occurs then correct the score and qgap and accordingly
while (query_align[0] == '-') { // gap at beginning ( or at the end of actual alignment currently its reversed )
ret.qgap--;
int l1 = ret.align_len;
// move alignment to right its equivalent to saying query_align = query_align+1;
for (int i = 0; i < l1; i++) {
query_align[i] = query_align[i + 1];
db_align[i] = db_align[i + 1];
}
ret.align_len--;
}
//print_score(ret);
while (query_align[ret.align_len - 1] == '-') {
ret.pos++; // string is reversed righnow to pos should increase when its at the end
ret.qgap--;
//ret.score -= obj_score_mat.gap_penalty;
query_align[ret.align_len - 1] = '\0';
db_align[ret.align_len - 1] = '\0';
ret.align_len--;
}
//print_score(ret);
reverse_str(db_align, ret.align_len);
reverse_str(query_align, ret.align_len);
return ret;
}
int min(int fu, int fd, int fl, char * ptr) {
int min = 0;
if (fd <= fu && fd <= fl) {
min = fd;
*ptr = '\\';
} else if (fu < fl) {
min = fu;
*ptr = '|';
} else {
min = fl;
*ptr = '-';
}
return min;
}
void print_matrix(int ** F, char * seq_1, char * seq_2, int L1, int L2) {
int i, j;
printf(" ");
for (j = 0; j < L1; j++) {
printf("%c ", seq_1[j]);
}
printf("\n");
for (i = 0; i <= L2; i++) {
if (i > 0) {
printf("%c ", seq_2[i - 1]);
}
for (j = 0; j <= L1; j++) {
//cout.width( 3 );
printf("%d ", F[i][j]);
}
printf("\n");
}
}
void print_traceback(char ** traceback, char * seq_1, char * seq_2, int L1,
int L2) {
char line[100] = "";
int i, j;
printf(" ");
for (j = 0; j < L1; j++) {
char tmp[4] = "";
sprintf(tmp, "%c ", seq_1[j]);
strcat(line, tmp);
}
printf(" %s \n", line);
line[0] = '\0';
for (i = 0; i <= L2; i++) {
char tmp[4] = "";
if (i > 0) {
sprintf(tmp, "%c ", seq_2[i - 1]);
strcat(line, tmp);
}
for (j = 0; j <= L1; j++) {
sprintf(tmp, "%c ", traceback[i][j]);
strcat(line, tmp);
}
printf("%s \n", line);
line[0] = '\0';
}
}
void print_al(char * db_align, char * query_align) {
printf("DB:\t%s\n", db_align);
printf("Q:\t%s\n", query_align);
}
void initialize_str(char *str, int len) {
int i;
for (i = 0; i < len; i++) {
str[i] = '\0';
}
}
void reverse_str(char *str, int len) {
char tmp;
//int len= strlen(str),i;
for (int i = 0; i < len / 2; i++) {
tmp = str[i];
str[i] = str[len - 1 - i];
str[len - 1 - i] = tmp;
}
}
void print_score(scoreinfo s) {
printf(
" Score: %d, n_iden: %d,Pos: %d Mismatch: %d, dgap: %d, s.qgap: %d, align_len %d\n",
s.score, s.n_iden, s.pos, s.mm, s.dgap, s.qgap, s.align_len);
}
/*
*
*/
#ifdef EXE
int main(int argc,char *argv[])
{
char *query = argv[1];
char *db = argv[2];
if(argc != 4 ) {
printf("%d , usage : ./a.out query db prm",argc);
return -1;
}
int prm = atoi(argv[3]);
int q_len = strlen(query);
int db_len = strlen(db);
char query_align[MAX],db_align[MAX];
initialize_str(query_align,MAX);
initialize_str(db_align,MAX);
scoreinfo score = edit_distance(query,db,q_len,db_len,query_align,db_align,prm);
print_score(score);
print_al(db_align,query_align);
}
#endif
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