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<table width=600 class=frame border=0><tr><td><table border=0 width=100% cellspacing=1 cellpadding=3><tr><td class=tag>InterPro Entry IPR001064</td></tr></table></td></tr></table>
<h2 class=name>Crystallin</h2>
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<td class=tag valign=top width=110>Database</td>
<td class=inf valign=top width=1200>InterPro</td></tr>
<tr>
<td class=tag valign=top width=110>Accession</td>
<td class=inf valign=top width=1200>IPR001064; Crystallin (matches 132 proteins)</td></tr>
<tr>
<td class=tag valign=top width=110>Name</td>
<td class=inf valign=top width=1200>Crystallin</td></tr>
<tr>
<td class=tag valign=top width=110>Type</td>
<td class=inf valign=top width=1200><A href="#" onClick='w=window.open("IHelpServlet?help=Domain", "helpwindow", "width=450,height=400,scrollbars=yes,resizable=yes");w.focus();'>
Domain
<img src="gifs/help.gif" width=19 height=19 border=0 alt=""></a></td></tr>
<tr>
<td class=tag valign=top width=110>Dates</td>
<td class=inf valign=top width=1200>08-OCT-1999 (created)<BR>05-DEC-2000 (last modified)</td></tr>
<tr>
<td class=tag valign=top width=110>Signatures</td>
<td class=inf valign=top width=1200>
<a href="http://www.expasy.ch/cgi-bin/nicesite.pl?PS00225">PS00225</a>; CRYSTALLIN_BETAGAMMA
(1586 proteins)<br><a href="http://methionine.sbc.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01367">PR01367</a>; BGCRYSTALLIN
(102 proteins)<br><a href="http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF00030">PF00030</a>; crystall
(113 proteins)<br><a href="http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=XTALbg&BLAST=DUMMY">SM00247</a>; XTALbg
(129 proteins)<br></td></tr>
<tr>
<td class=tag valign=top width=110><A href="#" onClick='w=window.open("IHelpServlet?help=abstract", "helpwindow", "width=450,height=400,scrollbars=yes,resizable=yes");w.focus();'>
Abstract
<img src="gifs/helptag.gif" width=19 height=19 border=0 alt=""></a></td>
<td class=inf valign=top width=1200>Crystallins are the dominant structural components of the eye lens. Among the
different type of crystallins, the beta and gamma crystallins form a family of
related proteins [1, 2]. Structurally, beta and gamma crystallins
are composed of two similar domains which, in turn, are each composed of two similar
motifs with the two domains connected by a short connecting peptide. Each motif,
which is about forty amino acid residues long, is folded in a distinctive
'Greek key' pattern.</td></tr>
<tr>
<td class=tag valign=top width=110>Examples</td>
<td class=inf valign=top width=1200><ul>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:P02966]">P02966</a> DESS_MYXXA: A calcium-binding protein from the sporulating bacterium Myxococcus xanthusa forms a major part of the spore coat</li>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:P46058]">P46058</a> EDSP_CYNPY</li>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:P09353]">P09353</a> SR3A_PHYPO: Spherulin 3a from the slime mold Physarum polycephalum. Spherulin 3a is a development specific protein synthesized in response to various kinds of stress leading to encystment and dormancy. The sequence of Spherulin 3a consists of two 'Greek key' motifs [3]</li>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:P06504]">P06504</a> CRBS_BOVIN</li>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:Q91314]">Q91314</a> CB12_RANCA</li>
<li><a href="http://srs6.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-newId+-e+[SWall-ACC:P07317]">P07317</a> CRBA_RANTE</li>
<br><a href="ISpy?ac=P02966,P46058,P09353,P06504,Q91314,P07317">View examples</a>
</td></tr>
<tr>
<td class=tag valign=top width=110>References</td>
<td class=inf valign=top width=1200><ol>
<li value=1><a name=PUB00000056>
Wistow G.J., Piatigorsky J.<br>
<i>Lens crystallins: the evolution and expression of proteins for a highly specialized tissue.</i><br>
Annu. Rev. Biochem. 57: 479-504(1988).
<a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=89024580&form=6&db=m&Dopt=b">[MEDLINE:89024580]</a>
[PUB00000056]
<li value=2><a name=PUB00004933>
Lubsen N.H., Aarts H.J.M., Schoenmakers J.G.G.<br>
<i>The evolution of lenticular proteins: the beta- and gamma-crystallin super gene family.</i><br>
Prog. Biophys. Mol. Biol. 51: 47-76(1988).
<a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=89113769&form=6&db=m&Dopt=b">[MEDLINE:89113769]</a>
[PUB00004933]
<li value=3><a name=PUB00003409>
Wistow G.<br>
<i>Evolution of a protein superfamily: relationships between vertebrate lens crystallins and microorganism dormancy proteins.</i><br>
J. Mol. Evol. 30: 140-145(1990).
<a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=90189184&form=6&db=m&Dopt=b">[MEDLINE:90189184]</a>
[PUB00003409]
</ol></td></tr>
<tr>
<td class=tag valign=top width=110>Database links</td><td class=inf valign=top width=1200>
PROSITE doc; <a href="http://www.expasy.ch/cgi-bin/nicedoc.pl?PDOC00197">PDOC00197</a><br>
Blocks; <a href="http://blocks.fhcrc.org/blocks-bin/getblock.sh?IPB001064">IPB001064</a><br>
</td></tr>
<tr>
<td class=tag valign=top width=110><A href="#" onClick='w=window.open("IHelpServlet?help=matches", "helpwindow", "width=450,height=400,scrollbars=yes,resizable=yes");w.focus();'>
Matches
<img src="gifs/helptag.gif" width=19 height=19 border=0 alt=""></a></td>
<td class=inf valign=top width=1200><a href="ISpy?ipr=IPR001064&display=n">Table</a> <a href="ISpy?ipr=IPR001064&display=n&dmax=20000">all</a> <a href="ISpy?ipr=IPR001064">Graphical</a> <a href="ISpy?ipr=IPR001064&dmax=20000">all</a> <a href="http://www.ebi.ac.uk/~flo/cgi-bin/InterPro_GUI/script/ReqInterPro.pl?list_ipr_ac=IPR001064">Condensed graphical view</a></td></tr>
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