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|
********************************************************************************
MAST - Motif Alignment and Search Tool
********************************************************************************
MAST version 3.0 (Release date: 2004/08/18 09:07:01)
For further information on how to interpret these results or to get
a copy of the MAST software please access http://meme.sdsc.edu.
********************************************************************************
********************************************************************************
REFERENCE
********************************************************************************
If you use this program in your research, please cite:
Timothy L. Bailey and Michael Gribskov,
"Combining evidence using p-values: application to sequence homology
searches", Bioinformatics, 14(48-54), 1998.
********************************************************************************
********************************************************************************
DATABASE AND MOTIFS
********************************************************************************
DATABASE adh.s (peptide)
Last updated on Mon Aug 16 21:19:59 2004
Database contains 33 sequences, 9996 residues
MOTIFS meme.adh.oops.txt (peptide)
MOTIF WIDTH BEST POSSIBLE MATCH
----- ----- -------------------
1 29 YSASKFAVRMLTRSMAHEYAPHGIRVNCI
2 29 KVVLITGCSSGIGKATAKHLHKEGAKVVL
PAIRWISE MOTIF CORRELATIONS:
MOTIF 1
----- -----
2 0.30
No overly similar pairs (correlation > 0.60) found.
Random model letter frequencies (from non-redundant database):
A 0.073 C 0.018 D 0.052 E 0.062 F 0.040 G 0.069 H 0.022 I 0.056 K 0.058
L 0.092 M 0.023 N 0.046 P 0.051 Q 0.041 R 0.052 S 0.074 T 0.059 V 0.064
W 0.013 Y 0.033
********************************************************************************
********************************************************************************
SECTION I: HIGH-SCORING SEQUENCES
********************************************************************************
- Each of the following 33 sequences has E-value less than 10.
- The E-value of a sequence is the expected number of sequences
in a random database of the same size that would match the motifs as
well as the sequence does and is equal to the combined p-value of the
sequence times the number of sequences in the database.
- The combined p-value of a sequence measures the strength of the
match of the sequence to all the motifs and is calculated by
o finding the score of the single best match of each motif
to the sequence (best matches may overlap),
o calculating the sequence p-value of each score,
o forming the product of the p-values,
o taking the p-value of the product.
- The sequence p-value of a score is defined as the
probability of a random sequence of the same length containing
some match with as good or better a score.
- The score for the match of a position in a sequence to a motif
is computed by by summing the appropriate entry from each column of
the position-dependent scoring matrix that represents the motif.
- Sequences shorter than one or more of the motifs are skipped.
- The table is sorted by increasing E-value.
********************************************************************************
SEQUENCE NAME DESCRIPTION E-VALUE LENGTH
------------- ----------- -------- ------
BUDC_KLETE ACETOIN(DIACETYL) REDUCTA... 2.6e-33 241
YRTP_BACSU HYPOTHETICAL 25.3 KD PROT... 4.3e-33 238
AP27_MOUSE ADIPOCYTE P27 PROTEIN (AP... 4.5e-33 244
HDE_CANTR HYDRATASE-DEHYDROGENASE-E... 1.6e-32 906
HDHA_ECOLI 7-ALPHA-HYDROXYSTEROID DE... 4.9e-31 255
DHII_HUMAN CORTICOSTEROID 11-BETA-DE... 8.2e-31 292
FIXR_BRAJA FIXR PROTEIN 2.6e-30 278
DHGB_BACME GLUCOSE 1-DEHYDROGENASE B... 3.2e-30 262
NODG_RHIME NODULATION PROTEIN G (HOS... 3.4e-29 245
RIDH_KLEAE RIBITOL 2-DEHYDROGENASE (... 6.2e-29 249
YINL_LISMO HYPOTHETICAL 26.8 KD PROT... 6.6e-29 248
DHMA_FLAS1 N-ACYLMANNOSAMINE 1-DEHYD... 1.2e-28 270
HMTR_LEIMA no comment 5.1e-28 287
2BHD_STREX 20-BETA-HYDROXYSTEROID DE... 5.9e-28 255
ENTA_ECOLI 2,3-DIHYDRO-2,3-DIHYDROXY... 4.8e-27 248
DHB2_HUMAN no comment 1.7e-26 387
BDH_HUMAN D-BETA-HYDROXYBUTYRATE DE... 2.8e-26 343
BA72_EUBSP 7-ALPHA-HYDROXYSTEROID DE... 4.2e-26 249
FVT1_HUMAN no comment 8.9e-26 332
GUTD_ECOLI SORBITOL-6-PHOSPHATE 2-DE... 5.1e-25 259
DHB3_HUMAN no comment 8.3e-25 310
3BHD_COMTE 3-BETA-HYDROXYSTEROID DEH... 1.4e-24 253
LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC... 8.1e-24 305
DHES_HUMAN ESTRADIOL 17 BETA-DEHYDRO... 2.4e-22 327
RFBB_NEIGO no comment 3.2e-19 346
BPHB_PSEPS BIPHENYL-CIS-DIOL DEHYDRO... 1e-18 275
YURA_MYXXA no comment 1.9e-18 258
PCR_PEA no comment 7.2e-18 399
DHCA_HUMAN no comment 1.1e-17 276
ADH_DROME ALCOHOL DEHYDROGENASE (EC... 2.7e-14 255
MAS1_AGRRA no comment 3e-14 476
FABI_ECOLI no comment 9.7e-14 262
CSGA_MYXXA no comment 2.5e-12 166
********************************************************************************
********************************************************************************
SECTION II: MOTIF DIAGRAMS
********************************************************************************
- The ordering and spacing of all non-overlapping motif occurrences
are shown for each high-scoring sequence listed in Section I.
- A motif occurrence is defined as a position in the sequence whose
match to the motif has POSITION p-value less than 0.0001.
- The POSITION p-value of a match is the probability of
a single random subsequence of the length of the motif
scoring at least as well as the observed match.
- For each sequence, all motif occurrences are shown unless there
are overlaps. In that case, a motif occurrence is shown only if its
p-value is less than the product of the p-values of the other
(lower-numbered) motif occurrences that it overlaps.
- The table also shows the E-value of each sequence.
- Spacers and motif occurences are indicated by
o -d- `d' residues separate the end of the preceding motif
occurrence and the start of the following motif occurrence
o [n] occurrence of motif `n' with p-value less than 0.0001.
********************************************************************************
SEQUENCE NAME E-VALUE MOTIF DIAGRAM
------------- -------- -------------
BUDC_KLETE 2.6e-33 2_[2]_120_[1]_61
YRTP_BACSU 4.3e-33 6_[2]_119_[1]_55
AP27_MOUSE 4.5e-33 7_[2]_112_[1]_67
HDE_CANTR 1.6e-32 8_[2]_125_[1]_131_[2]_115_[1]_411
HDHA_ECOLI 4.9e-31 11_[2]_74_[1]_15_[1]_68
DHII_HUMAN 8.2e-31 34_[2]_119_[1]_81
FIXR_BRAJA 2.6e-30 36_[2]_123_[1]_61
DHGB_BACME 3.2e-30 7_[2]_123_[1]_74
NODG_RHIME 3.4e-29 6_[2]_116_[1]_65
RIDH_KLEAE 6.2e-29 14_[2]_116_[1]_61
YINL_LISMO 6.6e-29 5_[2]_75_[2]_15_[1]_66
DHMA_FLAS1 1.2e-28 14_[2]_121_[1]_77
HMTR_LEIMA 5.1e-28 6_[2]_157_[1]_66
2BHD_STREX 5.9e-28 6_[2]_116_[1]_75
ENTA_ECOLI 4.8e-27 5_[2]_109_[1]_76
DHB2_HUMAN 1.7e-26 82_[2]_120_[1]_127
BDH_HUMAN 2.8e-26 55_[2]_123_[1]_107
BA72_EUBSP 4.2e-26 6_[2]_121_[1]_64
FVT1_HUMAN 8.9e-26 32_[2]_124_[1]_118
GUTD_ECOLI 5.1e-25 2_[2]_122_[1]_77
DHB3_HUMAN 8.3e-25 48_[2]_120_[1]_84
3BHD_COMTE 1.4e-24 6_[2]_115_[1]_74
LIGD_PSEPA 8.1e-24 6_[2]_121_[1]_120
DHES_HUMAN 2.4e-22 2_[2]_50_[2]_44_[1]_144
RFBB_NEIGO 3.2e-19 6_[2]_129_[1]_153
BPHB_PSEPS 1e-18 5_[2]_118_[1]_94
YURA_MYXXA 1.9e-18 65_[2]_22_[2]_14_[1]_70
PCR_PEA 7.2e-18 25_[1]_32_[2]_284
DHCA_HUMAN 1.1e-17 4_[2]_159_[1]_55
ADH_DROME 2.7e-14 6_[2]_116_[1]_75
MAS1_AGRRA 3e-14 245_[2]_74_[1]_14_[1]_56
FABI_ECOLI 9.7e-14 6_[2]_123_[1]_75
CSGA_MYXXA 2.5e-12 51_[2]_7_[1]_50
********************************************************************************
********************************************************************************
SECTION III: ANNOTATED SEQUENCES
********************************************************************************
- The positions and p-values of the non-overlapping motif occurrences
are shown above the actual sequence for each of the high-scoring
sequences from Section I.
- A motif occurrence is defined as a position in the sequence whose
match to the motif has POSITION p-value less than 0.0001 as
defined in Section II.
- For each sequence, the first line specifies the name of the sequence.
- The second (and possibly more) lines give a description of the
sequence.
- Following the description line(s) is a line giving the length,
combined p-value, and E-value of the sequence as defined in Section I.
- The next line reproduces the motif diagram from Section II.
- The entire sequence is printed on the following lines.
- Motif occurrences are indicated directly above their positions in the
sequence on lines showing
o the motif number of the occurrence,
o the position p-value of the occurrence,
o the best possible match to the motif, and
o columns whose match to the motif has a positive score (indicated
by a plus sign).
********************************************************************************
BUDC_KLETE
ACETOIN(DIACETYL) REDUCTASE (EC 1.1.1.5) (ACETOIN DEHYDROGENASE)
LENGTH = 241 COMBINED P-VALUE = 7.82e-35 E-VALUE = 2.6e-33
DIAGRAM: 2_[2]_120_[1]_61
[2]
7.9e-21
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++++++++++++++++ + +
1 MQKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATATAVAAEINQAGGRAVAIKVDVSRRDQVFAAVEQARK
[1]
2.6e-21
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++++++++++++ ++++++
151 VYSSSKFAVRGLTQTAARDLAPLGITVNGFCPGIVKTPMWAEIDRQCRKRRANRWATARLNLPNASPLAACRSLK
YRTP_BACSU
HYPOTHETICAL 25.3 KD PROTEIN IN RTP 5'REGION (ORF238)
LENGTH = 238 COMBINED P-VALUE = 1.31e-34 E-VALUE = 4.3e-33
DIAGRAM: 6_[2]_119_[1]_55
[2]
2.8e-19
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++++++++++++++++++++++ ++ +
1 MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVEKVAEEVKALGVKAAFAAADVKDADQVNQAVA
[1]
1.3e-22
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++++++++ ++++++++++++++++++++
151 VTSAYSASKFAVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVAQLKLDPR
AP27_MOUSE
ADIPOCYTE P27 PROTEIN (AP27)
LENGTH = 244 COMBINED P-VALUE = 1.37e-34 E-VALUE = 4.5e-33
DIAGRAM: 7_[2]_112_[1]_67
[2]
7.4e-20
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++++ ++++++++++++++
1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDATEKALGGIG
[1
4.
YS
++
76 PVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYS
]
8e-22
ASKFAVRMLTRSMAHEYAPHGIRVNCI
++++++++++++++++++++ ++++++
151 STKGAMTMLTKAMAMELGPHKIRVNSVNPTVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSD
HDE_CANTR
HYDRATASE-DEHYDROGENASE-EPIMERASE (HDE)
LENGTH = 906 COMBINED P-VALUE = 4.94e-34 E-VALUE = 1.6e-32
DIAGRAM: 8_[2]_125_[1]_131_[2]_115_[1]_411
[2]
2.5e-19
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++++++++++++ + +++++ ++++++
1 MSPVDFKDKVVIITGAGGGLGKYYSLEFAKLGAKVVVNDLGGALNGQGGNSKAADVVVDEIVKNGGVAVADYNNV
[1]
2.8e-13
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+ +++ ++ ++ ++++++ ++++++ +++
151 PAGLYGNFGQANYASAKSALLGFAETLAKEGAKYNIKANAIAPLARSRMTESILPPPMLEKLGPEKVAPLVLYLS
[2]
1.5e-24
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++ +++++++++++++++++++
301 TNEARKLPANDASGAPTVSLKDKVVLITGAGAGLGKEYAKWFAKYGAKVVVNDFKDATKTVDEIKAAGGEAWPDQ
[1]
5.2e-18
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++++++++ +++++++ + ++ +++++++
451 NITSTSGIYGNFGQANYSSSKAGILGLSKTMAIEGAKNNIKVNIVAPHAETAMTLTIFREQDKNLYHADQVAPLL
HDHA_ECOLI
7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (HSDH)
LENGTH = 255 COMBINED P-VALUE = 1.49e-32 E-VALUE = 4.9e-31
DIAGRAM: 11_[2]_74_[1]_15_[1]_68
[2]
4.3e-21
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++ +++++++++++++++++++
1 MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQEL
[1]
2.9e-05
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+ ++ ++++ + ++++ + +
76 SALADFAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAE
[1]
8.6e-19
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+ +++++ +++++ +++++++++++++++
151 NKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIA
DHII_HUMAN
CORTICOSTEROID 11-BETA-DEHYDROGENASE (EC 1.1.1.146) (11-DH) (11-BETA-
HYDROXYSTEROID DEHYDROGENASE) (11-BETA-HSD)
LENGTH = 292 COMBINED P-VALUE = 2.49e-32 E-VALUE = 8.2e-31
DIAGRAM: 34_[2]_119_[1]_81
[2]
3.9e-24
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++++++++++++++++++++
1 MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVV
[1]
1.2e-15
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++ ++ +++++ +++++++
151 TVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMK
FIXR_BRAJA
FIXR PROTEIN
LENGTH = 278 COMBINED P-VALUE = 7.83e-32 E-VALUE = 2.6e-30
DIAGRAM: 36_[2]_123_[1]_61
[2]
3.2e-18
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++ +++++++++++++ + ++++++
1 MGLDLPNDNLIRGPLPEAHLDRLVDAVNARVDRGEPKVMLLTGASRGIGHATAKLFSEAGWRIISCARQPFDGER
[1]
5.1e-21
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+ +++++ ++++++++++++++++++++
151 APILLAQGLFDELRAASGSIVNVTSIAGSRVHPFAGSAYATSKAALASLTRELAHDYAPHGIRVNAIAPGEIRTD
DHGB_BACME
GLUCOSE 1-DEHYDROGENASE B (EC 1.1.1.47)
LENGTH = 262 COMBINED P-VALUE = 9.77e-32 E-VALUE = 3.2e-30
DIAGRAM: 7_[2]_123_[1]_74
[2]
4.4e-19
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++ + +++++++++++++ +++++
1 MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEEIKKVGGEAIAVKGDVTVESDVIN
[1]
5.3e-20
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+ +++++++ +++++++++++++++++++
151 KIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPEQRADVESMIPMGYIGEPEE
NODG_RHIME
NODULATION PROTEIN G (HOST-SPECIFICITY OF NODULATION PROTEIN C)
LENGTH = 245 COMBINED P-VALUE = 1.03e-30 E-VALUE = 3.4e-29
DIAGRAM: 6_[2]_116_[1]_65
[2]
4.0e-16
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++ ++ ++++ ++++++ + +
1 MFELTGRKALVTGASGAIGGAIARVLHAQGAIVGLHGTQIEKLETLATELGDRVKLFPANLANRDEVKALGQRAE
[1]
7.3e-22
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++++++++++++ +++++++
151 NYCASKAGMIGFSKSLAQEIATRNITVNCVAPGFIESAMTDKLNHKQKEKIMVAIPIHRMGTGTEVASAVAYLAS
RIDH_KLEAE
RIBITOL 2-DEHYDROGENASE (EC 1.1.1.56) (RDH)
LENGTH = 249 COMBINED P-VALUE = 1.88e-30 E-VALUE = 6.2e-29
DIAGRAM: 14_[2]_116_[1]_61
[2]
7.0e-21
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++ +++++++++++++++++ +++++++
1 MKHSVSSMNTSLSGKVAAITGAASGIGLECARTLLGAGAKVVLIDREGEKLNKLVAELGENAFALQVDLMQADQV
[1]
7.4e-17
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++++++++++++++ +++++++++++ ++
151 VVPVIWEPVYTASKFAVQAFVHTTRRQVAQYGVRVGAVLPGPVVTALLDDWPKAKMDEALANGSLMQPIEVAESV
YINL_LISMO
HYPOTHETICAL 26.8 KD PROTEIN IN INLA 5'REGION (ORFA)
LENGTH = 248 COMBINED P-VALUE = 1.99e-30 E-VALUE = 6.6e-29
DIAGRAM: 5_[2]_75_[2]_15_[1]_66
[2]
2.9e-23
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++++++++++++++++ +++++++ ++
1 MTIKNKVIIITGASSGIGKATALLLAEKGAKLVLAARRVEKLEKIVQIIKANSGEAIFAKTDVTKREDNKKLVEL
[2]
3.8e-05
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+ + + ++ + +++ ++ +
76 AIERYGKVDAIFLNAGIMPNSPLSALKEDEWEQMIDINIKGVLNGIAAVLPSFIAQKSGHIIATSSVAGLKAYPG
[1]
1.9e-14
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++ +++ ++++ ++++ ++++
151 GAVYGATKWAVRDLMEVLRMESAQEGTNIRTATIYPAAINTELLETITDKETEQGMTSLYKQYGITPDRIASIVA
DHMA_FLAS1
N-ACYLMANNOSAMINE 1-DEHYDROGENASE (EC 1.1.1.233) (NAM-DH)
LENGTH = 270 COMBINED P-VALUE = 3.65e-30 E-VALUE = 1.2e-28
DIAGRAM: 14_[2]_121_[1]_77
[2]
2.0e-19
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+ +++++++++++++++++ +++++++++
1 TTAGVSRRPGRLAGKAAIVTGAAGGIGRATVEAYLREGASVVAMDLAPRLAATRYEEPGAIPIACDLADRAAIDA
[1]
4.2e-18
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+ ++++++ +++++++++++++++ ++++
151 GSVNSFMAEPEAAAYVAAKGGVAMLTRAMAVDLARHGILVNMIAPGPVDVTGNNTGYSEPRLAEQVLDEVALGRP
HMTR_LEIMA
no comment
LENGTH = 287 COMBINED P-VALUE = 1.55e-29 E-VALUE = 5.1e-28
DIAGRAM: 6_[2]_157_[1]_66
[2]
1.6e-17
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++++++++ +++++++ ++++++ +++
1 MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVS
[1]
2.1e-19
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++++++++++++ +++++++
151 PYFLIKAFAHRSRHPSQASRTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGL
2BHD_STREX
20-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.53)
LENGTH = 255 COMBINED P-VALUE = 1.78e-29 E-VALUE = 5.9e-28
DIAGRAM: 6_[2]_116_[1]_75
[2]
7.1e-18
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++++ + +++ +++++++++
1 MNDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAR
[1]
6.8e-19
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++++ +++++++ +++++++
151 SYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGNEPGEIAGAVVKLL
ENTA_ECOLI
2,3-DIHYDRO-2,3-DIHYDROXYBENZOATE DEHYDROGENASE (EC 1.3.1.28)
LENGTH = 248 COMBINED P-VALUE = 1.45e-28 E-VALUE = 4.8e-27
DIAGRAM: 5_[2]_109_[1]_76
[2]
3.7e-20
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++++++++++++++++++
1 MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDA
[1]
1.2e-15
YSASKFA
+++++++
76 LVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAA
VRMLTRSMAHEYAPHGIRVNCI
++++ + ++++ ++++++++
151 LKSLALSVGLELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFL
DHB2_HUMAN
no comment
LENGTH = 387 COMBINED P-VALUE = 5.05e-28 E-VALUE = 1.7e-26
DIAGRAM: 82_[2]_120_[1]_127
[2]
3.4e-17
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+ ++++++++++++++++++ + ++ +++
76 ELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYS
[1]
1.7e-18
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++++ ++++++++++++ ++
226 MERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
BDH_HUMAN
D-BETA-HYDROXYBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.30) (BDH)
(3-HYDROXYBUTYRATE DEHYDROGENASE) (FRAGMENT)
LENGTH = 343 COMBINED P-VALUE = 8.57e-28 E-VALUE = 2.8e-26
DIAGRAM: 55_[2]_123_[1]_107
[2]
2.3e-18
KVVLITGCSSGIGKATAKHL
+ +++++++++ ++++++++
1 GLRPPPPGRFSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHL
HKEGAKVVL
+++++ +++
76 HSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVFRSEEVEKVVGDCPFEPEGPEKGMWGLVNNAGISTF
[1]
5.5e-17
YSASKFAVRMLTRSMAHE
++ +++++++++++++++
151 GEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYE
YAPHGIRVNCI
+++ +++++++
226 MYPLGVKVSVVEPGNFIAATSLYNPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
BA72_EUBSP
7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (BILE ACID
7-DEHYDROXYLASE) (BILE ACID-INDUCIBLE PROTEIN)
LENGTH = 249 COMBINED P-VALUE = 1.28e-27 E-VALUE = 4.2e-26
DIAGRAM: 6_[2]_121_[1]_64
[2]
2.6e-18
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++++++ ++++++ ++ ++ +++++ +
1 MNLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSRDAVMAA
[1]
1.5e-16
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+ +++++++++++ + +++ +++++++++
151 SLSGVGYPASKASVIGLTHGLGREIIRKNIRVVGVAPGVVNTDMTNGNPPEIMEGYLKALPMKRMLEPEEIANVY
FVT1_HUMAN
no comment
LENGTH = 332 COMBINED P-VALUE = 2.70e-27 E-VALUE = 8.9e-26
DIAGRAM: 32_[2]_124_[1]_118
[2]
2.3e-17
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++++++++++++++++++++++ + +
1 MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKE
[1]
1.9e-17
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++ ++++++++++++++++
151 YPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFA
GUTD_ECOLI
SORBITOL-6-PHOSPHATE 2-DEHYDROGENASE (EC 1.1.1.140) (GLUCITOL-6- PHOSPHATE
DEHYDROGENASE) (KETOSEPHOSPHATE REDUCTASE)
LENGTH = 259 COMBINED P-VALUE = 1.54e-26 E-VALUE = 5.1e-25
DIAGRAM: 2_[2]_122_[1]_77
[2]
1.5e-14
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++ ++++ ++ +++ ++++++++ +
1 MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGESMAYGFGADATSEQSCLALSRGV
[1]
3.0e-19
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++ +++++++++++++++++++++
151 NSGYSAAKFGGVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGC
DHB3_HUMAN
no comment
LENGTH = 310 COMBINED P-VALUE = 2.53e-26 E-VALUE = 8.3e-25
DIAGRAM: 48_[2]_120_[1]_84
[2]
7.4e-19
KVVLITGCSSGIGKATAKHLHKEGAKV
+++++++++ ++++++ ++++++ ++
1 MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYYKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNV
VL
++
76 VLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEI
[1]
6.7e-15
YSASKFAVRMLTRSMAHEYAPHGIRVNC
++++++++++++++++ +++ + + +++
151 QSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV
I
+
226 LTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
3BHD_COMTE
3-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.51)
LENGTH = 253 COMBINED P-VALUE = 4.25e-26 E-VALUE = 1.4e-24
DIAGRAM: 6_[2]_115_[1]_74
[2]
2.6e-18
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++ ++++++ ++ +++++
1 TNRLQGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELGERSMFVRHDVSSEADWTLVMAAVQ
[1]
5.1e-15
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++++++++ +++++ +++
151 YSASKAAVSALTRAAALSCRKQGYAIRVNSIHPDGIYTPMMQASLPKGVSKEMVLHDPKLNRAGRAYMPERIAQL
LIGD_PSEPA
C ALPHA-DEHYDROGENASE (EC -.-.-.-)
LENGTH = 305 COMBINED P-VALUE = 2.45e-25 E-VALUE = 8.1e-24
DIAGRAM: 6_[2]_121_[1]_120
[2]
6.5e-17
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++ +++++++ ++ ++ + ++++++++
1 MKDFQDQVAFITGGASGAGFGQAKVFGQAGAKIVVADVRAEAVEKAVAELEGLGITAHGIVLDIMDREAYARAAD
[1]
7.9e-16
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++ +++++ +++ ++++++ ++++
151 SALAGPYSAAKAASINLMEGYRQGLEKYGIGVSVCTPANIKSNIAEASRLRPAKYGTSGYVENEESIASLHSIHQ
DHES_HUMAN
ESTRADIOL 17 BETA-DEHYDROGENASE (EC 1.1.1.62) (20 ALPHA-HYDROXYSTEROID
DEHYDROGENASE) (E2DH) (17-BETA-HSD) (PLACENTAL 17-BETA-HYDROXYSTEROID
DEHYDROGENASE)
LENGTH = 327 COMBINED P-VALUE = 7.31e-24 E-VALUE = 2.4e-22
DIAGRAM: 2_[2]_50_[2]_44_[1]_144
[2]
1.4e-14
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++++++++ +++++ ++ +
1 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAA
[2]
9.3e-05
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++ + ++ ++++ ++ + + + +
76 RERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLP
[1]
1.0e-16
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++++++++++ + + +++ + +
151 FNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQV
RFBB_NEIGO
no comment
LENGTH = 346 COMBINED P-VALUE = 9.68e-21 E-VALUE = 3.2e-19
DIAGRAM: 6_[2]_129_[1]_153
[2]
1.8e-13
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++++++++ ++ +++++ +++ ++
1 MQTEGKKNILVTGGAGFIGSAVVRHIIQNTRDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICDRAELDRVF
[1]
1.0e-14
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++ +++++++++ ++ ++ ++
151 DLFTETTPYAPSSPYSASKAAADHLVRAWQRTYRLPSIVSNCSNNYGPRQFPEKLIPLMILNALSGKPLPVYGDG
BPHB_PSEPS
BIPHENYL-CIS-DIOL DEHYDROGENASE (EC 1.3.1.-)
LENGTH = 275 COMBINED P-VALUE = 3.02e-20 E-VALUE = 1e-18
DIAGRAM: 5_[2]_118_[1]_94
[2]
8.6e-15
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++++++ +++++ ++
1 MKLKGEAVLITGGASGLGRALVDRFVAEAKVAVLDKSAERLAELETDLGDNVLGIVGDVRSLEDQKQAASRCVAR
[1]
1.2e-12
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++++++++++++++++++++++ + +
151 PLYTAAKQAIVGLVRELAFELAPYVRVNGVGPGGMNSDMRGPSSLGMGSKAISTVPLADMLKSVLPIGRMPEVEE
YURA_MYXXA
no comment
LENGTH = 258 COMBINED P-VALUE = 5.64e-20 E-VALUE = 1.9e-18
DIAGRAM: 65_[2]_22_[2]_14_[1]_70
[2]
5.6e-05
KVVLITGCSS
+ ++ ++
1 RQHTGGLHGGDELPDGVGDGCLQRPGTRAGAVARQAGVRVFAAGRRLPQLQAADEAPGGRRHRGARGVDVTKADA
[2]
5.7e-08
GIGKATAKHLHKEGAKVVL KVVLITGCSSGIGKATAKHLHKEGAKVVL
+ + +++ + + ++ + +++++ + + ++ ++ + +
76 TLERIRALDAEAGGLDLVVANAGVGGTTNAKRLPWERVRGIIDTNVTGAAATLSAVLPQMVERKRGHLVGVSSLA
[1]
3.8e-19
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+++++++++ ++++++++++ ++++++++
151 GFRGLPATRYSASKAFLSTFMESLRVDLRGTGVRVTCIYPGFVKSELTATNNFPMPFLMETHDAVELMGKGIVRG
PCR_PEA
no comment
LENGTH = 399 COMBINED P-VALUE = 2.17e-19 E-VALUE = 7.2e-18
DIAGRAM: 25_[1]_32_[2]_284
[1]
1.7e-08
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++ ++++++++++ + + +++ +
1 MALQTASMLPASFSIPKEGKIGASLKDSTLFGVSSLSDSLKGDFTSSALRCKELRQKVGAVRAETAAPATPAVNK
[2]
1.9e-18
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++++++++++++++++++ + ++
76 SSSEGKKTLRKGNVVITGASSGLGLATAKALAESGKWHVIMACRDYLKAARAAKSAGLAKENYTIMHLDLASLDS
DHCA_HUMAN
no comment
LENGTH = 276 COMBINED P-VALUE = 3.43e-19 E-VALUE = 1.1e-17
DIAGRAM: 4_[2]_159_[1]_55
[2]
4.0e-16
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++++++++++++++++++++ + ++
1 SSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDF
[1]
2.9e-10
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++ ++ +++ +++ +++ +++++ +++
151 PELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNAC
ADH_DROME
ALCOHOL DEHYDROGENASE (EC 1.1.1.1)
LENGTH = 255 COMBINED P-VALUE = 8.17e-16 E-VALUE = 2.7e-14
DIAGRAM: 6_[2]_116_[1]_75
[2]
1.1e-10
KVVLITGCSSGIGKATAKHLHKEGAKVVL
++++ + +++++ + ++++++ + +
1 SFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKL
[1]
3.6e-12
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++ ++++++++++++++ ++++ +++
151 VYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKA
MAS1_AGRRA
no comment
LENGTH = 476 COMBINED P-VALUE = 9.22e-16 E-VALUE = 3e-14
DIAGRAM: 245_[2]_74_[1]_14_[1]_56
[2]
2.9e-15
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++ + +++ ++++++++++++++ +
226 GRVLHFRRGFSHWTVEIHQSPVILVSGSNRGVGKAIAEDLIAHGYRLSLGARKVKDLEVAFGPQDEWLHYARFDA
[1]
4.0e-08
YSASKFAVRMLTRSMAHEYAPHGIRVN
+ + + +++ ++ + +++ +++
301 EDHGTMAAWVTAAVEKFGRIDGLVNNAGYGEPVNLDKHVDYQRFHLQWYINCVAPLRMTELCLPHLYETGSGRIV
[1]
8.7e-05
CI YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++ + +++ ++ +++++ ++ + +
376 NINSMSGQRVLNPLVGYNMTKHALGGLTKTTQHVGWDRRCAAIDICLGFVATDMSAWTDLIASKDMIQPEDIAKL
FABI_ECOLI
no comment
LENGTH = 262 COMBINED P-VALUE = 2.94e-15 E-VALUE = 9.7e-14
DIAGRAM: 6_[2]_123_[1]_75
[2]
4.5e-10
KVVLITGCSSGIGKATAKHLHKEGAKVVL
+++++++ ++ + ++ ++ +++ +
1 MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMF
[1]
3.1e-12
YSASKFAVRMLTRSMAHEYAPHGIRVNCI
++ +++++++ +++++ +++++++++++
151 RAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDV
CSGA_MYXXA
no comment
LENGTH = 166 COMBINED P-VALUE = 7.50e-14 E-VALUE = 2.5e-12
DIAGRAM: 51_[2]_7_[1]_50
[2]
9.0e-08
KVVLITGCSSGIGKATAKHLHKEG
+ ++ + ++ + +++ +++
1 MRAFATNVCTGPVDVLINNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLPGLRQGALRRVAHVTSRMG
[1]
1.3e-12
AKVVL YSASKFAVRMLTRSMAHEYAPHGIRVNCI
+ + ++++++ + ++++ ++++++ + + +
76 SLAANTDGGAYAYRMSKAALNMAVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNP
********************************************************************************
CPU: pmgm2
Time 0.250000 secs.
mast meme.adh.oops.txt -text -stdout
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