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<!DOCTYPE PubmedArticleSet PUBLIC "-//NLM//DTD PubMedArticle, 1st January 2018//EN" "https://dtd.nlm.nih.gov/ncbi/pubmed/out/pubmed_180101.dtd">
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<PubmedArticle>
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<PMID Version="1">27797938</PMID>
<DateCompleted>
<Year>2017</Year>
<Month>08</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised>
<Year>2018</Year>
<Month>04</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1468-3288</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>66</Volume>
<Issue>6</Issue>
<PubDate>
<Year>2017</Year>
<Month>06</Month>
</PubDate>
</JournalIssue>
<Title>Gut</Title>
<ISOAbbreviation>Gut</ISOAbbreviation>
</Journal>
<ArticleTitle>Leucocyte telomere length, genetic variants at the <i>TERT</i> gene region and risk of pancreatic cancer.</ArticleTitle>
<Pagination>
<MedlinePgn>1116-1122</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/gutjnl-2016-312510</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVE">Telomere shortening occurs as an early event in pancreatic tumorigenesis, and genetic variants at the telomerase reverse transcriptase (<i>TERT</i>) gene region have been associated with pancreatic cancer risk. However, it is unknown whether prediagnostic leucocyte telomere length is associated with subsequent risk of pancreatic cancer.</AbstractText>
<AbstractText Label="DESIGN">We measured prediagnostic leucocyte telomere length in 386 pancreatic cancer cases and 896 matched controls from five prospective US cohorts. ORs and 95% CIs were calculated using conditional logistic regression. Matching factors included year of birth, cohort (which also matches on sex), smoking status, fasting status and month/year of blood collection. We additionally examined single-nucleotide polymorphisms (SNPs) at the <i>TERT</i> region in relation to pancreatic cancer risk and leucocyte telomere length using logistic and linear regression, respectively.</AbstractText>
<AbstractText Label="RESULTS">Shorter prediagnostic leucocyte telomere length was associated with higher risk of pancreatic cancer (comparing extreme quintiles of telomere length, OR 1.72; 95% CI 1.07 to 2.78; p<sub>trend</sub>=0.048). Results remained unchanged after adjustment for diabetes, body mass index and physical activity. Three SNPs at <i>TERT</i> (linkage disequilibrium r<sup>2</sup><0.25) were associated with pancreatic cancer risk, including rs401681 (per minor allele OR 1.33; 95% CI 1.12 to 1.59; p=0.002), rs2736100 (per minor allele OR 1.36; 95% CI 1.13 to 1.63; p=0.001) and rs2736098 (per minor allele OR 0.75; 95% CI 0.63 to 0.90; p=0.002). The minor allele for rs401681 was associated with shorter telomere length (p=0.023).</AbstractText>
<AbstractText Label="CONCLUSIONS">Prediagnostic leucocyte telomere length and genetic variants at the <i>TERT</i> gene region were associated with risk of pancreatic cancer.</AbstractText>
<CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</CopyrightInformation>
</Abstract>
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<Author ValidYN="Y">
<LastName>Bao</LastName>
<ForeName>Ying</ForeName>
<Initials>Y</Initials>
<AffiliationInfo>
<Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Prescott</LastName>
<ForeName>Jennifer</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
<Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Yuan</LastName>
<ForeName>Chen</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Zhang</LastName>
<ForeName>Mingfeng</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation>
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<LastName>Kraft</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Babic</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Morales-Oyarvide</LastName>
<ForeName>Vicente</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Qian</LastName>
<ForeName>Zhi Rong</ForeName>
<Initials>ZR</Initials>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Buring</LastName>
<ForeName>Julie E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo>
<Affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Cochrane</LastName>
<ForeName>Barbara B</ForeName>
<Initials>BB</Initials>
<AffiliationInfo>
<Affiliation>University of Washington School of Nursing, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Gaziano</LastName>
<ForeName>J Michael</ForeName>
<Initials>JM</Initials>
<AffiliationInfo>
<Affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Giovannucci</LastName>
<ForeName>Edward L</ForeName>
<Initials>EL</Initials>
<AffiliationInfo>
<Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Manson</LastName>
<ForeName>JoAnn E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo>
<Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ng</LastName>
<ForeName>Kimmie</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ogino</LastName>
<ForeName>Shuji</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Division of MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Rohan</LastName>
<ForeName>Thomas E</ForeName>
<Initials>TE</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.</Affiliation>
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<Author ValidYN="Y">
<LastName>Sesso</LastName>
<ForeName>Howard D</ForeName>
<Initials>HD</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Stampfer</LastName>
<ForeName>Meir J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo>
<Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Fuchs</LastName>
<ForeName>Charles S</ForeName>
<Initials>CS</Initials>
<AffiliationInfo>
<Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>De Vivo</LastName>
<ForeName>Immaculata</ForeName>
<Initials>I</Initials>
<AffiliationInfo>
<Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Amundadottir</LastName>
<ForeName>Laufey T</ForeName>
<Initials>LT</Initials>
<AffiliationInfo>
<Affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Wolpin</LastName>
<ForeName>Brian M</ForeName>
<Initials>BM</Initials>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation>
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<Language>eng</Language>
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