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<?xml version="1.0" ?>
<!DOCTYPE PubmedArticleSet PUBLIC "-//NLM//DTD PubMedArticle, 1st June 2018//EN" "https://dtd.nlm.nih.gov/ncbi/pubmed/out/pubmed_180601.dtd">
<PubmedArticleSet>
<PubmedArticle>
<MedlineCitation Status="In-Data-Review" Owner="NLM">
<PMID Version="1">28775130</PMID>
<DateRevised>
<Year>2018</Year>
<Month>04</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1470-7926</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>75</Volume>
<Issue>2</Issue>
<PubDate>
<Year>2018</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Occupational and environmental medicine</Title>
<ISOAbbreviation>Occup Environ Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators.</ArticleTitle>
<Pagination>
<MedlinePgn>79-89</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/oemed-2017-104431</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Animal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic studies have examined this association. We evaluated the relationship between individual pesticides and thyroid function in 679 men enrolled in a substudy of the Agricultural Health Study, a cohort of licensed pesticide applicators.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Self-reported lifetime pesticide use was obtained at cohort enrolment (1993-1997). Intensity-weighted lifetime days were computed for 33 pesticides, which adjusts cumulative days of pesticide use for factors that modify exposure (eg, use of personal protective equipment). Thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3) and antithyroid peroxidase (anti-TPO) autoantibodies were measured in serum collected in 2010-2013. We used multivariate logistic regression to estimate ORs and 95% CIs for subclinical hypothyroidism (TSH >4.5 mIU/L) compared with normal TSH (0.4-<u><</u>4.5 mIU/L) and for anti-TPO positivity. We also examined pesticide associations with TSH, T4 and T3 in multivariate linear regression models.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Higher exposure to the insecticide aldrin (third and fourth quartiles of intensity-weighted days vs no exposure) was positively associated with subclinical hypothyroidism (OR<sub>Q3</sub>=4.15, 95% CI 1.56 to 11.01, OR<sub>Q4</sub>=4.76, 95% CI 1.53 to 14.82, p<sub>trend</sub> <0.01), higher TSH (p<sub>trend</sub>=0.01) and lower T4 (p<sub>trend</sub>=0.04). Higher exposure to the herbicide pendimethalin was associated with subclinical hypothyroidism (fourth quartile vs no exposure: OR<sub>Q4</sub>=2.78, 95% CI 1.30 to 5.95, p<sub>trend</sub>=0.02), higher TSH (p<sub>trend</sub>=0.04) and anti-TPO positivity (p<sub>trend</sub>=0.01). The fumigant methyl bromide was inversely associated with TSH (p<sub>trend</sub>=0.02) and positively associated with T4 (p<sub>trend</sub>=0.01).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our results suggest that long-term exposure to aldrin, pendimethalin and methyl bromide may alter thyroid function among male pesticide applicators.</AbstractText>
<CopyrightInformation>© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Lerro</LastName>
<ForeName>Catherine C</ForeName>
<Initials>CC</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Beane Freeman</LastName>
<ForeName>Laura E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>DellaValle</LastName>
<ForeName>Curt T</ForeName>
<Initials>CT</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Environmental Working Group, Washington, DC, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kibriya</LastName>
<ForeName>Muhammad G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo>
<Affiliation>Department of Public Health Sciences, The University of Chicago, Chicago, Illinois, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Aschebrook-Kilfoy</LastName>
<ForeName>Briseis</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Department of Public Health Sciences, The University of Chicago, Chicago, Illinois, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Jasmine</LastName>
<ForeName>Farzana</ForeName>
<Initials>F</Initials>
<AffiliationInfo>
<Affiliation>Department of Public Health Sciences, The University of Chicago, Chicago, Illinois, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Koutros</LastName>
<ForeName>Stella</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Parks</LastName>
<ForeName>Christine G</ForeName>
<Initials>CG</Initials>
<AffiliationInfo>
<Affiliation>National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Sandler</LastName>
<ForeName>Dale P</ForeName>
<Initials>DP</Initials>
<AffiliationInfo>
<Affiliation>National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Alavanja</LastName>
<ForeName>Michael C R</ForeName>
<Initials>MCR</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Biology, Hood College, Frederick, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Hofmann</LastName>
<ForeName>Jonathan N</ForeName>
<Initials>JN</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ward</LastName>
<ForeName>Mary H</ForeName>
<Initials>MH</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y">
<Grant>
<GrantID>Z01 CP010119</GrantID>
<Acronym>CP</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant>
<GrantID>Z01 ES049030</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant>
<GrantID>Z99 CA999999</GrantID>
<Acronym>NULL</Acronym>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2017</Year>
<Month>08</Month>
<Day>03</Day>
</ArticleDate>
</Article>
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<Country>England</Country>
<MedlineTA>Occup Environ Med</MedlineTA>
<NlmUniqueID>9422759</NlmUniqueID>
<ISSNLinking>1351-0711</ISSNLinking>
</MedlineJournalInfo>
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<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">agriculture</Keyword>
<Keyword MajorTopicYN="N">hypothyroidism</Keyword>
<Keyword MajorTopicYN="N">pesticides</Keyword>
<Keyword MajorTopicYN="N">thyroid disease</Keyword>
<Keyword MajorTopicYN="N">thyroid stimulating hormone</Keyword>
</KeywordList>
<CoiStatement>Competing interests: None declared.</CoiStatement>
</MedlineCitation>
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<History>
<PubMedPubDate PubStatus="received">
<Year>2017</Year>
<Month>03</Month>
<Day>10</Day>
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<PubMedPubDate PubStatus="revised">
<Year>2017</Year>
<Month>06</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2017</Year>
<Month>06</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pmc-release">
<Year>2019</Year>
<Month>02</Month>
<Day>01</Day>
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<Month>8</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Day>5</Day>
<Hour>6</Hour>
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<Month>8</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<ArticleId IdType="doi">10.1136/oemed-2017-104431</ArticleId>
<ArticleId IdType="pmc">PMC5771820</ArticleId>
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|
