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#!/usr/bin/env perl
use strict;
use warnings;
use FindBin;
use lib ("$FindBin::RealBin/../../PerlLib");
use BHStats;
my $usage = "usage: $0 fpkm.matrix\n\n";
my $matrix = $ARGV[0] or die $usage;
my $pseudocount = 0.1;
main: {
open (my $fh, $matrix) or die $!;
my $header = <$fh>;
while (<$fh>) {
chomp;
my @x = split(/\t/);
my $gene_id = shift @x;
my $bi = &tukey_biweight(@x);
my $sum = 0;
foreach my $val (@x) {
$val = abs($val - $bi) + $pseudocount;
$sum += $val + $pseudocount;
}
my $entropy = 0;
foreach my $val (@x) {
my $ratio = $val/$sum;
$entropy += $ratio * log($ratio)/log(2);
}
$entropy *= -1;
print "$gene_id\t$entropy\n";
}
exit(0);
}
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